Comparative Analysis of SUV Measurements Using Different Correction Methods in Oncological PET/CT Imaging.

NCT07306975 | Not Yet Recruiting

• 1 other identifier: SUV measurements in PET/CT
• Study Type: observational
• Target: 80
• Locations: 0 countries
• Sites: N/A

Brief Summary

-To measure SUVs by using different correction methods in oncological PET/CT imaging.

Conditions

Cancer Patients Referred to do PET/CT Study

Keywords

SUV measurements , correction, PET/CT

Outcome Measures

Primary Outcomes (1)

• -To measure SUVs by using different correction methods in oncological PET/CT imaging.

  -To compare between SUV measurements in the tumor and liver using different standardizing parameters such as: body weight, lean body mass and body surface area.

  1/12/2025 to 1/10/2027

Secondary Outcomes (1)

• To determine if SUVbsa is more accurate than SUVbw in obese patients.

  1/12/2025 to 1/10/2027

Interventions

PET/CT with 18-FDG DEVICE

* Patients will fast for at least 4 hrs before imaging with blood glucose level (\<200 mg/dl) before intravenous administration of F18-FDG. * Imaging will be performed approximately 45 to 60 min after 18F-FDG injection, an imaging field of view from the base of skull to mid-thighs with the arms above the head whenever possible is used or otherwise the arms are positioned beside the body.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

\- Cancer patients (\> 18 years old) referred to nuclear medicine unit to do F18-FDG PET/CT study.

You may qualify if:

• Cancer patients (\> 18 years old) referred to nuclear medicine unit to do F18-FDG PET/CT study.

You may not qualify if:

• Patients \< 18 years old.
• Patients with increased FDG uptake on tissue associated with non-malignant causes such as diffuse bone marrow FDG uptake or inflammatory.
• Patients with extensive metastasis.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (4)

• Kim CK, Gupta NC, Chandramouli B, Alavi A. Standardized uptake values of FDG: body surface area correction is preferable to body weight correction. J Nucl Med. 1994 Jan;35(1):164-7.

  PMID: 8271040 RESULT

• Nakaichi T, Funamoto K, Yamashita S, Yamamoto H, Yokoyama K. Clinical Usefulness of Standardized Uptake Value Normalized to Lean Body Mass Measured Using a Body Composition Analyzer. Cureus. 2025 May 30;17(5):e85089. doi: 10.7759/cureus.85089. eCollection 2025 May.

  PMID: 40589668 RESULT

• Azmi NHM, Suppiah S, Liong CW, Noor NM, Said SM, Hanafi MH, et al. Reliability of standarized uptake value normalized to lean body mass using the liver as a reference organ, in contrast-enhanced 18F-FDG PET/CT imaging. Radiography. 2018;24(2):112-117. doi:10.1016/j.radi.2017.09.006.

  RESULT

• Ahmed A, Ali M, Salah H, Eisa RE, Mohieldin H, Omer H, et al. Evaluation of uptake values of FDG: Body surface area Vs. body weight correction. Radiat Phys Chem. 2022;201:110482. doi:10.1016/j.radphyschem.2022.110482 .

  RESULT

MeSH Terms

Interventions

Positron Emission Tomography Computed Tomography

Intervention Hierarchy (Ancestors)

Positron-Emission Tomography; Tomography, Emission-Computed; Image Interpretation, Computer-Assisted; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Tomography, X-Ray Computed; Multimodal Imaging; Radiographic Image Enhancement; Image Enhancement; Photography; Radiography; Tomography, X-Ray; Radionuclide Imaging; Tomography; Diagnostic Techniques, Radioisotope

Study Officials

• Hanan Gamal Eldin Mostafa, Professor, doctor

  Assiut University

  STUDY CHAIR

Central Study Contacts

HebatAllah Ahmed AbdelRaoof Askar, Assistant Professor, doctor

CONTACT

+2001003040898; hebaaskar@aun.edu.eg

Aya Kamel Hamed Ahmed, Resident doctor

CONTACT

+2001097763423; aya.17289799@med.aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident doctor

Study Record Dates

• First Submitted: December 13, 2025
• First Posted: December 29, 2025
• Study Start: December 10, 2025
• Primary Completion (Estimated): October 1, 2027
• Study Completion (Estimated): December 1, 2027
• Last Updated: December 29, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL