Volumetric Parameter of 18F-FDG PET/CT in Characterizing Thyroid Incidentalomas

NCT07163806 | Not Yet Recruiting

• 1 other identifier: thyroid incidentaloma PET/CT
• Study Type: observational
• Target: 88
• Locations: 0 countries
• Sites: N/A

Brief Summary

To assess the clinical significance of FDG-avid thyroid incidentalomas detected on PET/CT and explore correlations between SUV max, ultrasound characteristics, and histopathology for suspicious lesion.

Conditions

Thyroid Incidentalomas

Outcome Measures

Primary Outcomes (1)

• Assess the clinical significance of FDG-avid thyroid incidentalomas on PET/CT

  Assess the clinical significance of FDG-avid thyroid incidentalomas on PET/CT and explore correlations between SUVmax, TIRAD system on ultrasound, and final histopathology for suspicious lesion.

  3 years

Interventions

PET/CT with 18-FDG DIAGNOSTIC_TEST

Patients will fast for at least four hours before imaging with blood glucose level \<200 mg /dL before intravenous administration of about 3.7 MBq/kg (0.1 mCi/kg). Imaging will be performed approximately 45 to 60 min after 18F-FDG injection , an imaging field of view from the base of skull to mid thighs with the arms above the head whenever possible is used or otherwise the arms are positioned beside the body. The semiquantitative analysis will be done using standardized uptake values (SUV). The SUV calculation will be done via the default method by body weight \[(SUV = mean ROI activity (MBq/g)/injected activity (MBq)/body weight (g)\]. For measurement of SUVs of lesion, multiple circular ROIs will be drawn covering the lesion over its entire length. For healthy organs, a circular ROI of 10 mm diameter will be drawn

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All Adult patients referred for 18F-FDG PET/CT and found to have thyroid incidentalomas,

You may qualify if:

• All Adult patients referred for 18F-FDG PET/CT and found to have thyroid incidentalomas,

You may not qualify if:

• o Known history of thyroid malignancy.
• Previous thyroid surgery .

Sponsors & Collaborators

• Fatma Abelzaher Mahmoud Ahmed: lead

Related Publications (1)

• Achury C, Estorch M, Domenech A, Camacho V, Flotats A, Jaller R, Geraldo L, Deportos J, Montes A, Carrio I. [Interpretation of thyroid incidentalomas in (18)F-FDG PET/CT studies]. Rev Esp Med Nucl Imagen Mol. 2014 Jul-Aug;33(4):205-9. doi: 10.1016/j.remn.2013.12.006. Epub 2014 Feb 21. Spanish.

  PMID: 24560597 RESULT

MeSH Terms

Interventions

Positron Emission Tomography Computed Tomography

Intervention Hierarchy (Ancestors)

Positron-Emission Tomography; Tomography, Emission-Computed; Image Interpretation, Computer-Assisted; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Tomography, X-Ray Computed; Multimodal Imaging; Radiographic Image Enhancement; Image Enhancement; Photography; Radiography; Tomography, X-Ray; Radionuclide Imaging; Tomography; Diagnostic Techniques, Radioisotope

Central Study Contacts

hemat abdelsamea, MD

CONTACT

+2010053226; Hemat.ahmad2012@aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: fatma abdelzaher

Study Record Dates

• First Submitted: September 2, 2025
• First Posted: September 9, 2025
• Study Start: October 30, 2025
• Primary Completion (Estimated): April 30, 2028
• Study Completion (Estimated): May 30, 2028
• Last Updated: September 29, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share