Efficacy of i-PRF Usage in Vestibular Socket Therapy

NCT07304986 | Active Not Recruiting

• 1 other identifier: 921/1704
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims for evaluation of A novel method for evaluating i-PRF usage in vestibular socket therapy for immediate implant in defective fresh extraction site.

Conditions

Esthetic Zone

Outcome Measures

Primary Outcomes (1)

• assessment of pink aesthetic score of the gingiva

  Assessment of clinical and aesthetic parameters after the newly proposed immediate implant placement technique. using pik aesthetic score of gingiva, The Pink Esthetic Score (PES) is a dental assessment tool scoring gingival aesthetics around implants, evaluating mesial/distal papillae, tissue level/contour/color/texture, and alveolar deficiency. Scoring System 0 (Poor): Marked deficiency or abnormality. 1. (Fair): Slight change or minor discrepancy. 2. (Excellent): Healthy, normal, ideal appearance.

  6 and 9 months.

Secondary Outcomes (1)

• Facial bone thickness

  base line, 6 and 9 months.

Study Arms (2)

deficient facial plate of bone management VST only

EXPERIMENTAL

Sockets with deficient facial plate of bone and intact soft tissue will receive VST only.

Procedure: Immediate implant with VST

deficient facial plate of bone management with VST and iPRF.

ACTIVE COMPARATOR

Sockets with deficient facial plate of bone and intact soft tissue will receive VST and iPRF.

Procedure: Immediate implant with VST and i-prf

Interventions

Immediate implant with VST PROCEDURE

Preoperative procedure: cone beam computed tomography (CBCT) scan will be used for diagnosis and treatment planning. Nonsurgical periodontal treatment including scaling and root planning will be performed as needed. Under local anesthesia sulcular incisions will be made, and then hopeless teeth will be extracted atraumatically using periotomes. Socket lavage and curettage will be done thoroughly, and dental implants will be inserted.

deficient facial plate of bone management VST only

Immediate implant with VST and i-prf PROCEDURE

Preoperative procedure: cone beam computed tomography (CBCT) scan will be used for diagnosis and treatment planning. Nonsurgical periodontal treatment including scaling and root planning will be performed as needed. Under local anesthesia sulcular incisions will be made, and then hopeless teeth will be extracted atraumatically using periotomes. Socket lavage and curettage will be done thoroughly, and dental implants will be inserted with i-prf.

deficient facial plate of bone management with VST and iPRF.

Eligibility Criteria

• Age: 15 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Patients has one hopeless tooth in the maxillary anterior region with TYPE II according to Elian classification of sockets (10) and sufficient bone apically and palatally.
• The presence of a natural contralateral tooth for the tooth being replaced.

You may not qualify if:

• Extraction sockets were grade III.
• Acute infection related to hopeless tooth.
• Allergy to any material or medication used in the study.
• Medically compromised patients according to modified Cornell Medical Index.
• Heavy smokers.

Sponsors & Collaborators

• Al-Azhar University: lead

Study Sites (1)

AlAzharU

Cairo, Nasr City, 11371, Egypt

Location

MeSH Terms

Interventions

proliferation regulatory factors, human urine

Study Officials

• abdullah el-shamy, MSC

  Al-Azhar University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant lecturer of periodontology

Study Record Dates

• First Submitted: July 31, 2024
• First Posted: December 26, 2025
• Study Start: November 21, 2023
• Primary Completion: January 21, 2026
• Study Completion: March 21, 2026
• Last Updated: December 26, 2025

Record last verified: 2025-12

Locations

EG (1)