Association Between One Lung Ventilation and Myocardial Injury Markers (Troponin T and I) in Thoracic Surgical Procedures (OLVTIS)

NCT07302243 | Completed DMC

• 2 other identifiers: UNSOED - OLV108/KEPK/PE/2025
• Study Type: observational
• Target: 39
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective single-group cohort study aims to investigate the association between the One-Lung Ventilation (OLV) technique and myocardial injury, as measured by postoperative Troponin T and Troponin I levels, in patients undergoing thoracic surgery. All eligible participants will undergo standardized anesthesia and OLV techniques, with cardiac biomarkers collected before surgery and six hours postoperatively. The findings of this study are expected to provide a better understanding of the impact of OLV on myocardial stress or injury during thoracic surgical procedures.

Conditions

Thoracic Anesthesia; One Lung Ventillation (OLV)

Keywords

one lung ventilation; thoracic surgery; troponin; myocardial infarction

Outcome Measures

Primary Outcomes (1)

• Change in Troponin T Levels Pre- and Post-Thoracotomy with One-Lung Ventilation

  Troponin T levels are measured before surgery and again 6-12 hours after the thoracotomy procedure to evaluate myocardial injury potentially associated with one-lung ventilation.

  Pre operative baseline and 6 - 12 hours post operative

Study Arms (1)

Thoracotomy OLV

A single cohort of adult patients undergoing thoracotomy with one-lung ventilation. All participants receive standard general anesthesia. No interventions are assigned. Preoperative and postoperative cardiac biomarkers (Troponin T and I) and arterial blood gases are collected to evaluate myocardial injury associated with OLV.

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

* Patients who refuse to participate in the study * Patients undergoing thoracotomy surgery involving manipulation of the cardiovascular system * Patients with a history of heart disease and/or current cardiac treatment * Patients with severe hepatic or renal impairment * Patients with contraindications or allergies to the medications used in the study * Pregnant or Lactating women

You may qualify if:

• Patients aged 18-60 years who requiring surgical thoracotomy with one lung ventilation
• Classified as ASA Physical Status I - III
• Provide Informed concent ( patient or legal representative)

Sponsors & Collaborators

• Universitas Jenderal Soedirman: lead
• RS Prof. Dr. Margono Soekardjo Purwokerto: collaborator

Study Sites (1)

RSUD Prof. Margono Soekarjo

Purwokerto, Central Java, 53122, Indonesia

Location

MeSH Terms

Conditions

Myocardial Infarction

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Officials

• Rania Adeastri Hapsari, M.D

  Department of Anesthesiology and Intensive Care, Faculty of Medicine Jenderal Soedirman University / RSUD Prof. Dr. Margono Soekarjo Purwokerto. Purwokerto, Indonesia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Consultant Neuroanesthesiologist and Dean, Faculty of Medicine, Jenderal Soedirman University

Study Record Dates

• First Submitted: December 11, 2025
• First Posted: December 24, 2025
• Study Start: July 1, 2025
• Primary Completion: September 30, 2025
• Study Completion: September 30, 2025
• Last Updated: December 24, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

ID (1)