COMPARISON OF EFFECTS OF GABAPENTIN AND CLONIDINE ON POST-OPERATIVE PAIN AND ANXIETY IN LUMBAR SPINAL SURGERY.

NCT07297888 | Completed DMC

• 1 other identifier: 14
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

the investigators have tested whether gabapentin is superior to clonidine top decrease the post operative pain during spinal surgeries as a part of their thesis study. the investigators are registering this study post date as the student forgot by mistake to do so.

Conditions

Pain

Keywords

gabapentin; clonidine; pain

Outcome Measures

Primary Outcomes (1)

• post operative pain

  Pain was assessed using the Visual Analog Scale (VAS) score ranging from 0 to 10. 10 being the worst pain and 0 being No pain

  1, 2, 4, 6, 8, 12, and 24 hours postoperatively.

Secondary Outcomes (1)

• anxiety

  1, 2, 4, 6, 8, 12, and 24 hours postoperatively.

Study Arms (3)

clonide

ACTIVE COMPARATOR

In this group the investigators have given clonidine to the participants

Drug: Gabapentin

placebo

PLACEBO COMPARATOR

in this group no active drug was given to the participants

Drug: Gabapentin

gabapentin

ACTIVE COMPARATOR

In this group the investigators have given gabapentin to the participants

Drug: Gabapentin

Interventions

Gabapentin DRUG

comparison of both these drugs to decrease pain

Also known as: clonidine

clonide; gabapentin; placebo

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• \- Eligible participants were aged 18-60 years, classified as ASA physical status I or II, and scheduled for one or two-level lumbar laminectomy.

You may not qualify if:

• Patients with psychiatric disorders, autoimmune diseases, local infection, BMI \>35, emergency procedures, tumour surgeries and the patients requiring the postoperative ventilation were excluded

Sponsors & Collaborators

• Shri Guru Ram Rai Institute of Medical and Health Sciences: lead

Study Sites (1)

Adabala Vijay Babu

Dehradun, Uttarakhand, 246001, India

Location

MeSH Terms

Conditions

Pain

Interventions

Gabapentin; Clonidine

Condition Hierarchy (Ancestors)

Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Amines; Organic Chemicals; gamma-Aminobutyric Acid; Aminobutyrates; Butyrates; Acids, Acyclic; Carboxylic Acids; Cyclohexanecarboxylic Acids; Acids, Carbocyclic; Cyclohexanes; Cycloparaffins; Hydrocarbons, Alicyclic; Hydrocarbons, Cyclic; Hydrocarbons; Amino Acids; Amino Acids, Peptides, and Proteins; Imidazolines; Imidazoles; Azoles; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, CARE PROVIDER
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: ABabu

Study Record Dates

• First Submitted: November 19, 2025
• First Posted: December 22, 2025
• Study Start: July 20, 2022
• Primary Completion: January 20, 2024
• Study Completion: March 20, 2024
• Last Updated: January 12, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL

Locations

IN (1)