Arthroscopic Anterior Release Versus Discectomy as Treatments for Temporomandibular Joint Disc Displacement With Reduction

NCT07297459 | Enrolling By Invitation

• 1 other identifier: 2025-03211-01
• Study Type: observational
• Target: 65
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to compare and evalute the surgical intervention discectomy to arthroscopic anterior release due to the diagnosis temporomandibular joint disc displacement with reduction. The main questions it aims to answer are:

• which of the two surgical methods that best improves maximum interincisal opening, temporomandibular joint pain, and temporomandibular joint function.
• could any pre- or peri-operative variable/-s be identified as a predictor for outcome.
• are there any differences in how fast the patient recover after anterior release and discectomy, respectively.
• are there differences regarding postoperative hospitalisation, operating time, negative side effects? Researchers will compare the six-month surgical outcome regarding the above stated interventions. Study participants have already had their intervention, i.e. the study is retrospective.

Conditions

TMD; TMJ - Injury of Meniscus of Temporomandibular Joint; TMJ - Oral &Amp;Maxillofacial Surgery

Outcome Measures

Primary Outcomes (1)

• Maximum interincisal opening

  The maximum opening of the mouth measured with a millimetre ruler between the incisal edge of teeth 11 and 41. The change in opening before surgery compared with postoperative will be analysed.

  6 months

Secondary Outcomes (1)

• TMJ pain

  6 months

Study Arms (2)

Discektomy

Patients that have undergone discectomy of the TMJ due to disc displacement with reduction.

Anterior release

Patients that have undergone anterior release of the TMJ due to disc displacement with reduction.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Discectomy cohort: all patients with DDwR and surgically treated at the Department of Oral- and Maxillofacial Surgery, Karolinska University Hospital, Stockholm, during the years 2014-2017. Anterior release cohort: all patients with DDwR and surgically treated at the Department of Oral- and Maxillofacial Surgery, Karolinska University Hospital, Stockholm, during the years 2019-2025.

You may qualify if:

• Uni- or bilateral DDwR verified with clinical and/or magnetic resonance imaging (MRI) findings
• TMJ pain ≥ 3 (NRS) and/or TMJ disability ≥ 3 (NRS)
• Age ≥ 18 years

You may not qualify if:

• Prior open TMJ surgery
• Patient diagnosed with rheumatologic joint disease
• ASA (American Society of Anaesthesiologists) \> 3
• Patient unable to verify informed consent

Sponsors & Collaborators

• Karolinska Institutet: lead

Study Sites (1)

Karolinska University Hospital

Stockholm, 17176, Sweden

Location

Related Publications (24)

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Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: December 9, 2025
• First Posted: December 22, 2025
• Study Start: September 16, 2025
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: December 30, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will share

Locations

SE (1)