Ultrasonographic Evaluation of Talar Cartilage Thickness in Patients With Spinal Cord Injury

NCT07293949 | Recruiting

• 1 other identifier: 172
• Study Type: observational
• Target: 76
• Locations: 1 country
• Sites: 1

Brief Summary

Spinal cord injury patients often present with musculoskeletal comorbidities, including osteoarthritis. Early detection of cartilage damage is important for preventing osteoarthritis progression. This study aims to compare the talar cartilage thicknesses of spinal cord injury patients with healthy subjects. The secondary aim is to investigate a correlation between the talar cartilage thickness and disease-related parameters. The patient group is to be assessed for talar cartilage thickness (via ultrasound), functional status, spasticity, and ambulation levels.

Conditions

Osteoarthritis (OA); Spinal Cord Injuries (SCI)

Keywords

spinal cord injury; osteoarthritis; musculoskeletal ultrasound; talar cartilage

Outcome Measures

Primary Outcomes (1)

• Talar cartilage thickness

  The talar cartilage of both lower extremities are to be assessed with ultrasound

  Baseline

Secondary Outcomes (3)

• Functional Independence Measure (FIM) score

  Baseline

• Modified Ashworth Scale (MAS)

  Baseline

• Walking Index for Spinal Cord Injury II (WISCI II)

  Baseline

Study Arms (2)

Patient group

Spinal cord injury patients

Control group

Age, sex, and BMI matched healthy controls

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Thirty-eight SCI patients who apply to Physical Medicine and Rehabilitation outpatient and inpatient clinic between November 2025-January 2026 will be included in the study. Thirty-eight age, gender, and BMI-matched healthy participants who are literate, give oral and written consent without any additional disease will be formed as the control group.

You may qualify if:

• Aged between 18 to 60 years,
• Cervical, thoracal or lumber level of spinal cord injury
• AIS (American Spinal Injury Association Impairment Scale) Level A, B, C, or D
• Assisted ambulation of any kind
• Literacy
• Giving oral and written consent to participate in the study

You may not qualify if:

• Patients with sacral level injury
• AIS E
• MAS 4 level of spasticity
• History of any lower extremity operation
• History of fracture
• Botulinum toxin injection in the last 6 months
• Existing diagnosis of any rheumatologic or endocrine diseases

Sponsors & Collaborators

• Gaziosmanpasa Research and Education Hospital: lead

Study Sites (1)

Gaziosmanpasa Training and Research Hospital

Istanbul, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Spinal Cord Injuries; Osteoarthritis

Condition Hierarchy (Ancestors)

Spinal Cord Diseases; Central Nervous System Diseases; Nervous System Diseases; Trauma, Nervous System; Wounds and Injuries; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 22, 2025
• First Posted: December 19, 2025
• Study Start: December 20, 2025
• Primary Completion: February 1, 2026
• Study Completion: March 1, 2026
• Last Updated: February 2, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP
• Time Frame: Beginning 3 months and ending 3 years after the publication of results

Locations

TU (1)