The Risk of Second Primary Gastrointestinal Malignancies Following Primary Gastrointestinal Carcinoid Tumors: a SEER Based Study 2000-2022

NCT07291752 | Completed

• 1 other identifier: A276
• Study Type: observational
• Target: 93,481
• Locations: 0 countries
• Sites: N/A

Brief Summary

Carcinoid tumors are rare neuroendocrine tumors with slowly progressive course. Carcinoid tumors are the most common gastrointestinal (GI) neuroendocrine tumors. The most common sites of GI carcinoids are small intestine accounting for 45%, rectum (20%), appendix (17%), colon (11%), and stomach (7%). Some studies reported an association between neuroendocrine tumors and multiple malignancies. However, the presence of neuroendocrine tumors combined with multiple primary GI tumors is considered an exotic event in the literature with only few case studies and case series. So the aim of this study is to assess the risk of GI malignancies following primary GI carcinoids.

Conditions

Carcinoid Tumor; Second Primary Malignant Neoplasm

Keywords

SEER; Carcinoid; malignancy

Outcome Measures

Primary Outcomes (2)

• The standardized incidence ratio and excess risk of second primary gastrointestinal malignancies following primary gastrointestinal carcinoid tumors

  The surveillance, epidemiology and End Results (SEER) database was used to calculate the standardized incidence ratio (SIR) as Observed/Expected (O/E) and calculated the excess risk for second primary gastrointestinal malignancies following primary gastrointestinal carcinoid tumors

  Jan, 2000 till Dec, 2022

• The standardized incidence ratio and excess risk of gastrointestinal second primary malignancies stratified according to the primary gastrointestinal carcinoids site.

  from Jan, 2000 till Dec, 2022

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

patients diagnosed with gastrointestinal carcinoid tumor

You may qualify if:

• patients diagnosed with gastrointestinal carcinoid tumor.
• patients diagnosed from 2000 till 2022

You may not qualify if:

• patients diagnosed with autopsy only or death certificate only.
• patients lacking age documentation.

Sponsors & Collaborators

• Suez Canal University: lead

MeSH Terms

Conditions

Carcinoid Tumor; Neoplasms, Second Primary; Neoplasms

Condition Hierarchy (Ancestors)

Neuroendocrine Tumors; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms, Nerve Tissue

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident physician of gastroenterology

Study Record Dates

• First Submitted: December 5, 2025
• First Posted: December 18, 2025
• Study Start: December 1, 2000
• Primary Completion: December 30, 2022
• Study Completion: December 30, 2022
• Last Updated: December 18, 2025

Record last verified: 2025-12