A Two-decade Mortality Risk Analysis of Gastrointestinal Carcinoid Neoplasms: an Updated SEER-based Study 2000-2022

NCT07317713 | Completed

• 1 other identifier: A277
• Study Type: observational
• Target: 93,481
• Locations: 0 countries
• Sites: N/A

Brief Summary

Carcinoid tumors are rare neuroendocrine tumors with slowly progressive course with the sites are small intestine accounting for 45%, rectum (20%), appendix (17%), colon (11%), and stomach (7%). This study focus on the mortality risk analysis for GI carcinoids due to data insufficiency in the literature.

Conditions

Carcinoid Tumor

Outcome Measures

Primary Outcomes (1)

• The standardized mortality ratio of GI carcinoid tumors

  SEER\*Stat software (version 9.0.42.0) was used to conduct data extraction and statistical analysis. The MP-SIR session was used to calculate the SMR as Observed/Expected (O/E) with a 95% confidence interval (CI) and the excess risk was per 10,000. Statistical significance was achieved at 0.05. With further analysis, we compared cancer as a cause of death to other non-cancer causes of death across different time intervals and primary sites among GI carcinoid tumour.

  2000-2022

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The inclusion criteria involved all patients with primary malignant GI carcinoid tumor diagnosed between 2000 and 2022 with sequence number 0 or 1. Sequence 0 indicated the patient had only one cancer record while sequence 1 indicated the patient may had developed many cancer records following the first one. In addition, the tumors were restricted to malignant behavior codes (ICD-O-3 Code 3).

You may qualify if:

• patients diagnosed with gastrointestinal carcinoid tumor
• from 2000-2022
• histologically confirmed

You may not qualify if:

• death certificate only and autopsy only patients
• patients with unknown age data.

Sponsors & Collaborators

• Suez Canal University: lead

MeSH Terms

Conditions

Carcinoid Tumor

Condition Hierarchy (Ancestors)

Neuroendocrine Tumors; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms; Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms, Nerve Tissue

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident physician of gastroenterology

Study Record Dates

• First Submitted: December 19, 2025
• First Posted: January 5, 2026
• Study Start: December 1, 2000
• Primary Completion: December 30, 2022
• Study Completion: December 30, 2022
• Last Updated: January 5, 2026

Record last verified: 2025-12