Management of Supraventricular Tachycardias in Children

NCT07291544 | Completed

• 1 other identifier: WALDMANN202501
• Study Type: observational
• Target: 1,400
• Locations: 0 countries
• Sites: N/A

Brief Summary

Background Supraventricular tachycardias (SVTs) are the most common arrhythmic events in children, with an estimated incidence of 13 per 100,000 per year before the age of 18. Few large patient cohorts have been reported, as most published studies are single-center. Large-scale studies come from medico-administrative databases, which lack the granularity needed for detailed analysis of outcomes according to the therapies used and the type of SVT. Furthermore, although a large proportion of neonatal SVTs do not recur (spontaneous resolution of the accessory pathway), there are limited comparative data on the effectiveness of antiarrhythmic therapies specifically in children after the age of 1 year. Management therefore varies greatly, in part because current guidelines propose different therapeutic options based on low-level evidence. Objectives:

• Describe the management of SVTs (antiarrhythmic therapies and catheter ablation) in children in France
• Compare the effectiveness of different antiarrhythmic treatments according to age (\<1 year and \>1 year) and type of SVT
• Analyze the incidence of adverse events and complications associated with antiarrhythmic treatments and catheter ablation

Conditions

Supraventricular Arrhythmias; Children; Management

Keywords

supraventricular arrhythmias; supraventricular tachycardia; children

Outcome Measures

Primary Outcomes (3)

• Antiarrhythmic therapies

  Proportion of antiarrhythmic therapies used by age group (\<1 year and \>1 year)

  At the time of the first supraventricular tachycardia recorded

• Catheter ablation

  Proportion of children referred for catheter ablation and age at ablation

  At the time of first episode of supraventricular tachycardia or after recurrence

• Recurrence of supraventricular tachycardia

  Time between antiarrhythmic therapy initiation and first recurrence, according to treatment and age

  At 1 year after antiarrhythmic drug initiation

Interventions

Management of children with supraventricular tachycardias OTHER

Observational analysis of the management of supraventricular tachycardias (antiarrhythmic drugs and catheter ablations)

Eligibility Criteria

• Age: 0 Years - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

All children \<18 years old with a documented episode (ECG, Holter-ECG, wearable device, or implantable device) of sustained SVT (\>30 seconds) will be eligible. Although most children in this context do not have structural heart disease, those with congenital or structural heart disease will also be eligible. Participation will be proposed to all pediatric cardiology centers in France through the Filiale de Cardiologie Pédiatrique et Congénitale (FCPC).

You may qualify if:

• Age \<18 years at the time of the first documented supraventricular tachycardia episode

You may not qualify if:

• Early postoperative supraventricular tachycardia (\<30 days)
• Age ≥18 years at the first documented supraventricular tachycardia episode
• Fetal tachycardias without postnatal recurrence
• Atrial extrasystoles without sustained runs (\<30 seconds)

Sponsors & Collaborators

• Paris Cardiovascular Research Center (Inserm U970): lead

MeSH Terms

Conditions

Tachycardia, Supraventricular

Condition Hierarchy (Ancestors)

Tachycardia; Arrhythmias, Cardiac; Heart Diseases; Cardiovascular Diseases; Cardiac Conduction System Disease; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of pediatric and congenital electrophysiology

Study Record Dates

• First Submitted: December 5, 2025
• First Posted: December 18, 2025
• Study Start: January 1, 2000
• Primary Completion: September 30, 2025
• Study Completion: September 30, 2025
• Last Updated: January 2, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share