Effect of the Use of Oocyte-specific or Universal Vitrification and Warming Media on Pregnancy Rates in the Context of Oocyte Donation
Sponsor study identifier
observational
111
1 country
1
Study Start
July 1, 2015
Actual (reported)Primary Completion
July 2, 2020
Actual (reported)Study Completion
August 1, 2021
Actual (reported)Vitrification has become the gold standard for oocyte and embryo cryopreservation. Several commercial kits are available on the market, some are designed for specific developmental stages (e.g. oocytes, zygotes, cleavage-stage embryos or blastocysts) and others are suitable for several stages, therefore termed "universal". Oocytes, cleavage-stage embryos and blastocysts display different levels of resistance to cryopreservation, due to stage-specific properties. While the composition and the exposition protocol of stage specific media are optimized for specific developmental stages, "universal" media display a single composition, therefore exposition protocols should be adapted to each specific developmental stage to ensure optimal survival rates. The main objective of this study is to determine whether the shift from "oocyte specific" vitrification and warming media to "universal" media has an impact oocyte survival, embryological and clinical outcomes.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 1, 2021
Actual (reported)Click on a node to explore related trials.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
July 1, 2015
Actual (reported)July 2, 2020
Actual (reported)August 1, 2021
Actual (reported)December 4, 2025
Actual (reported)December 17, 2025
Actual (reported)Impact of vitrification and warming media on clinical pregnancy rate per fresh embryo transfer
number of clinical pregnancies (one or more gestational sacs visualized in ultrasonography) expressed per 100 embryo transfers
UltraSound at 1 month after embryo transfer
Impact of vitrification and warming media on oocyte survival rate
two hours after warming procedure
Impact of vitrification and warming media on fertilization rate
16-18 hours
Impact of vitrification and warming media on day-2 embryo percentage
43-45 hours
Impact of vitrification and warming media on top-quality embryo percentage
43-45 hours
Impact of vitrification and warming media on blastulation rate
114-118 hours
41 oocyte recipient ICSI cycles for which the initial oocyte vitrification procedure was performed with "oocyte- specific" medium RapidVit™ Oocyte (Vitrolife) and the warming procedure was performed with "oocyte-specific" medium RapidWarm™ Oocyte (Vitrolife)
39 oocyte recipient ICSI cycles for which the initial oocyte vitrification procedure was performed with "oocyte- specific" medium RapidVit™ Oocyte (Vitrolife) and the warming procedure was performed with "universal" medium RapidWarm™ Omni (Vitrolife)
31 oocyte recipient ICSI cycles for which the initial oocyte vitrification procedure was performed with "universal" medium RapidVit™ Oocyte (Vitrolife) and the warming procedure was performed with "universal" medium RapidWarm™ Omni (Vitrolife)
Different combinations of the vitrification and warming media were used for oocyte vitrification procedure in the context of oocyte donation
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Oocyte recipient couples undergoing an oocyte donation ICSI
CHU Clermont-Ferrand
Clermont-Ferrand, Auvergne, 63003, France
Florence Brugnon
University Hospital, Clermont-Ferrand
111 participants (actual enrollment reported by the registry).
First Submitted
December 4, 2025
First Posted
December 17, 2025
Study Start
July 1, 2015
Actual (reported)Use of Clomiphene Citrate as an Inhibitor of Ovulation in an Oocyte Cryopreservation Cycle
Contact the study team to confirm eligibility.
Primary Completion
July 2, 2020
Actual (reported)Study Completion
August 1, 2021
Actual (reported)Last Updated
January 28, 2026
Record last verified: 2024-04
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Source: ClinicalTrials.gov.
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