Lost in the Labyrinth: Predicting Central Neurological Causes of Vertigo Dizziness and Unsteadiness in the Emergency Department. A Multicentre Cross-sectional Observational Study

NCT07287891 | Recruiting

• 1 other identifier: VERTIGO
• Study Type: observational
• Target: 825
• Locations: 1 country
• Sites: 1

Brief Summary

This study will assess the sensitivity and specificity of the bedside examination algorithm performed by ED physicians. Finally, it aims to identify predictors of a central cause of the symptoms. This will consequently reduce the rate of misdiagnosis as well as the costs and length of stay due to inappropriate neuroimaging.

Conditions

Dizziness; Unsteadiness; ED With Vertigo

Outcome Measures

Primary Outcomes (1)

• The AUC of the bedside examination algorithm performed by ED physicians

  up to 36 months

Secondary Outcomes (2)

• identification of predictors of true positive patients

  up to 36 months

• evaluation of number of neuroimaging tests (TC and angio-TC) performed to patients with vertigo in the ED.tests performed

  up to 36 months

Study Arms (1)

Patients presenting at the ED with vertigo, dizziness, and unsteadiness

Patients presenting to the ED with vertigo/ dizziness

Diagnostic Test: Bedside examination of Vertigo

Interventions

Bedside examination of Vertigo DIAGNOSTIC_TEST

ED visit comprehensive of bedside examination of vertigo performed by trained EP or emergency medicine residents

Patients presenting at the ED with vertigo, dizziness, and unsteadiness

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients presenting at the ED with vertigo, dizziness or unsteadiness

You may qualify if:

• Patients presenting at the ED with vertigo, dizziness or unsteadiness
• \>= 18 years of age
• Patients able to give their consent

You may not qualify if:

• Patients with dementia
• Bedridden patients (for causes other than the current symptoms)
• Patients with obvious neurological findings presenting with vertigo but with suspected stroke at triage

Sponsors & Collaborators

• Fondazione IRCCS Policlinico San Matteo di Pavia: lead

Study Sites (1)

SC Pronto Soccorso e Medicina d'Urgenza, Fondazione IRCCS Policlinico San Matteo

Pavia, Pavia, 27100, Italy

RECRUITING

MeSH Terms

Conditions

Dizziness

Condition Hierarchy (Ancestors)

Sensation Disorders; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Marco Bonzano, MD

CONTACT

+390382502039; m.bonzano@smatteo.pv.it

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: December 4, 2025
• First Posted: December 17, 2025
• Study Start: January 26, 2024
• Primary Completion (Estimated): February 26, 2027
• Study Completion (Estimated): February 26, 2027
• Last Updated: December 17, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will not share

Locations

IT (1)