Dietary Inflammatory Index and Periodontal Status in Obese Patients

NCT07287553 | Recruiting

• 1 other identifier: RecepTayyip ErdoganUniversity
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

In this study aimed to investigate the effect of nutrition on periodontal status in individuals diagnosed with obesity and without any other systemic disease, and to investigate the relationship between DII and periodontal disease risk. A total of 200 participants will be included in the study. Participants' overall daily Dietary Inflammatory Index (DII) scores will be calculated. The obtained scores will be divided into four groups, from low to high: Q1 (n=50), Q2 (n=50), Q3 (n=50), and Q4 (n=50). According to the DII, groups Q1 and Q2, which include lower scores, represent individuals on an anti-inflammatory diet, while groups Q3 and Q4, which include higher scores, represent individuals on a pro-inflammatory diet. Interleukin (IL)-1β, IL-10, total oxidant status (TOS), and total antioxidant status (TAS) were collected from gingival crevicular fluid (GCF) and serum samples. The levels of biomarkers such as malondialdehyde (MDA), glutathione (GSH), leptin, adiponectin, tumor necrosis factor (TNF)-α and C-reactive protein (CRP) from serum samples alone will be analyzed by ELISA method at the Recep Tayyip Erdoğan University Medical Biochemistry Laboratory.

Conditions

Obesity

Keywords

obesity; periodontal status; dietary inflammatory index

Outcome Measures

Primary Outcomes (2)

• Periodontal pocket depth

  The distance between the pocket base and the gingival margin will be measured. It will be measured from the six surfaces of each tooth and the average will be taken higher scores indicate worse outcome.

  baseline

• Clinical attachment loss

  It will be calculated by measuring the distance between the cementoenemal border and the pocket base. It will be measured from the six surfaces of each tooth and the average will be taken higher scores indicate worse outcome.

  baseline

Secondary Outcomes (10)

• interleukin (IL)-1β level

  baseline

• interleukin (IL)-10 level

  baseline

• total oxidant status (TOS) level

  baseline

• total antioxidant status (TAS) level

  baseline

• serum leptin level

  baseline

Study Arms (4)

anti-inflammatory diet group 1

Individuals on an anti-inflammatory diet

Other: Periodontal indices will be obtained; Other: serum and crevicular fluid samples will be collected

anti-inflammatory diet group 2

Individuals on an anti-inflammatory diet

Other: Periodontal indices will be obtained; Other: serum and crevicular fluid samples will be collected

pro-inflammatory diet group 1

individuals on a pro-inflammatory diet

Other: Periodontal indices will be obtained; Other: serum and crevicular fluid samples will be collected

pro-inflammatory diet group 2

individuals on a pro-inflammatory diet

Other: Periodontal indices will be obtained; Other: serum and crevicular fluid samples will be collected

Interventions

Periodontal indices will be obtained OTHER

Periodontal indices will be obtained from all participants

anti-inflammatory diet group 1; anti-inflammatory diet group 2; pro-inflammatory diet group 1; pro-inflammatory diet group 2

serum and crevicular fluid samples will be collected OTHER

Serum and gingival crevicular fluid samples will be collected from all participants.

anti-inflammatory diet group 1; anti-inflammatory diet group 2; pro-inflammatory diet group 1; pro-inflammatory diet group 2

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Recep Tayyip Erdoğan University

You may qualify if:

• Being diagnosed with obesity,
• Not having any systemic conditions other than obesity (systemic diseases that may affect periodontal health, such as cardiovascular disease, chronic kidney disease, Type 1 diabetes, Type 2 diabetes, and hypertension (\>130/85 mmHg)),
• Being between the ages of 18 and 65,
• Not smoking or consuming alcohol,
• Not having used anti-inflammatory medications in the last 3 months, or antibiotics or systemic corticosteroids in the last 6 months,
• Not being pregnant or lactating,
• Not having received periodontal treatment in the last 6 months,
• Not having received nutritional advice in the last 3 months,
• Obesity diagnosis: BMI \> 30 kg/m2 or waist circumference: \> 100 cm for men and \> 90 cm for women.

You may not qualify if:

• Non-obese
• Having any systemic disease other than obesity (such as cardiovascular disease, chronic kidney disease, Type 1 diabetes, Type 2 diabetes, and hypertension (\>130/85 mmHg) that may affect periodontal health)
• Being over 65 years old and under 18 years old
• Smoking and alcohol use
• Having used anti-inflammatory drugs in the last 3 months, antibiotics, or systemic corticosteroids in the last 6 months
• Being pregnant or lactating
• Having received periodontal treatment in the last 6 months
• Having received nutritional advice in the last 3 months

Sponsors & Collaborators

• Recep Tayyip Erdogan University Training and Research Hospital: lead

Study Sites (1)

Recep Tayyip Erdoğan University

Rize, 53020, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Hatice Yemenoglu

CONTACT

+905052977517; htcymnglu@hotmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: November 17, 2025
• First Posted: December 17, 2025
• Study Start: November 22, 2025
• Primary Completion: February 21, 2026
• Study Completion: March 21, 2026
• Last Updated: December 17, 2025

Record last verified: 2025-11

Locations

TU (1)