Identifying Candidates for Limited Dissection at Microdissection TESE.

NCT07286279 | Completed

• 1 other identifier: Mini incision Micro-TESE
• Study Type: observational
• Target: 248
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this retrospective observational study is to learn whether certain clinical characteristics can help predict which infertile men may successfully have sperm retrieved using a less-invasive "mini-incision" version of micro-TESE. The study focuses on men with very low or absent sperm counts (non-obstructive azoospermia, cryptozoospermia, or severe OAT). The main questions it aims to answer are: Can sperm be successfully found using only a small, limited-dissection micro-TESE in some men? Which clinical factors (such as hormone levels or medical history) help identify men who may benefit from this less-invasive approach? Researchers will compare men who had successful sperm retrieval with the mini-incision alone to men who required a more extensive micro-TESE to see if certain characteristics predict which approach is likely to work.

Conditions

Non Obstructive Azoospermia; Cryptozoospermia; Oligoasthenoteratozoospermia; Male Infertility

Keywords

micro-TESE; male infertility; non-obstructive azoospermia; cryptozoospermia; oligoasthenoteratozoospermia; mini-incision

Outcome Measures

Primary Outcomes (1)

• Successful sperm retrieval rate defined as the presence of spermatozoa during limited dissection (mini-incision) micro-TESE

  At the time of limited dissection (mini-incision)

Secondary Outcomes (5)

• Serum FSH levels

  At baseline

• Serum testosterone levels

  At baseline

• Testicular volume

  At baseline

• Genetic abnormalities rate

  At baseline

• Procedure conversion from limited to extensive micro-TESE rate

  At the time of limited dissection (mini-incision)

Eligibility Criteria

• Age: 18 Years+
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Men who underwent micro-TESE procedure from March 2015 to June 2025

You may qualify if:

• Patients with cryptozoospermia or non obstructive azoospermia that underwent a micro-TESE

You may not qualify if:

• Patients with a potentially reversible cause of cryptozoospermia (i.e., presence of a varicocele, febrile illness, or recent toxin exposure)
• Patients with suspected partial genital tract obstruction (i.e post-vaso-vasostomy, post-vasoepididymostomy, and low volume cryptozoospermia with ejaculatory duct obstruction)
• Patients who have previously undergone a micro-TESE, TESA or TESE procedure

Sponsors & Collaborators

• Clinique Ovo: lead

Study Sites (1)

Clinique ovo

Montreal, Quebec, H4P 2S4, Canada

Location

MeSH Terms

Conditions

Oligospermia; Infertility, Male

Condition Hierarchy (Ancestors)

Genital Diseases, Male; Genital Diseases; Urogenital Diseases; Infertility; Male Urogenital Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 3, 2025
• First Posted: December 16, 2025
• Study Start: December 15, 2025
• Primary Completion: December 31, 2025
• Study Completion: January 15, 2026
• Last Updated: February 27, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)