Analysis of Risk Factors and Prognostic Predictive Value in Sepsis Patients With Nutritional Risk

NCT07278167 | Completed DMC

• 1 other identifier: AHInnerMongolia-NT
• Study Type: observational
• Target: 400
• Locations: 1 country
• Sites: 1

Brief Summary

Sepsis is a common critical illness in intensive care units, characterized by systemic inflammatory response, immune dysfunction, microcirculatory issues, and multi-organ failure. These factors lead to high mortality rates and poor prognoses for patients. Nutritional risk is a significant complication in patients with sepsis, with a prevalence of 38% - 78. Sepsis-induced hypermetabolism and hypercatabolism result in increased energy expenditure and accelerated protein breakdown in affected patients, which subsequently exacerbates the risk of malnutrition. Malnutrition weakens immune function, reduces resistance to infections, and impairs immune regulation in sepsis patients. It worsens organ dysfunction, prolongs ICU hospitalization, and increases morbidity and mortality rates. Early identification and intervention for potential risk factors in patients with sepsis, particularly those with nutritional risk, is crucial for enhancing their prognosis. There is a notable lack of sensitive indicators for assessing the prognosis of sepsis patients at nutritional risk. Recent studies have begun exploring physical assessment measures in ICU settings as accessible and noninvasive tools for evaluation. This study aims to investigate the predictive value of nutritional laboratory indicators and physical measurements regarding the 28-day outcomes of ICU patients with sepsis and nutritional risk, providing a foundation for early clinical intervention.

Conditions

Sepsis; Nutritional Risk

Outcome Measures

Primary Outcomes (1)

• 28-day clinical outcome

  28day

Study Arms (1)

survivors/non-survivors

Other: Retrospective data analysis, no intervention

Interventions

Retrospective data analysis, no intervention OTHER

Retrospective data analysis, no intervention

survivors/non-survivors

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Sepsis with nutritional risk

You may qualify if:

• Met the diagnostic criteria for sepsis 3.0
• Met the diagnostic criteria for nutritional risk (NRS-2002 score ≥ 3)
• ICU stay≥2 days
• Age ≥ 18

You may not qualify if:

• Edema
• Tumor patients
• Pregnancy
• Lack of complete laboratory results

Sponsors & Collaborators

• The Affiliated Hospital of Inner Mongolia Medical University: lead

Study Sites (1)

Jing Lin

Hohhot, China

Location

MeSH Terms

Conditions

Sepsis

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 30, 2025
• First Posted: December 11, 2025
• Study Start: March 1, 2025
• Primary Completion: July 1, 2025
• Study Completion: July 1, 2025
• Last Updated: December 11, 2025

Record last verified: 2025-11

Locations

CN (1)