Clinical Characteristics and Molecular Mechanism of Patients With Obstructive Sleep Apnea

NCT07277608 | Recruiting

• 1 other identifier: 2023-ke-450
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

To clarify the clinical features of patients with obstructive sleep apnea; To construct a multi-omics database of patients with obstructive sleep apnea, and compare the effects of different degrees of sleep apnea on prognosis, immunity, and metabolism. The medium and long-term prognosis, complications, comorbidities, risk factors, and immune and metabolic dynamics of patients with sleep apnea after treatment were studied. To elucidate the biomarkers and therapeutic targets associated with obstructive sleep apnea.

Conditions

Obstructive Sleep Apnea

Outcome Measures

Primary Outcomes (1)

• Multiple-omics features

  ELISA ,proteomics and metabolomics were performed on blood, saliva, urine

  Within 24 hours of admission，and samples of patients receiving treatment were also collected six months and one year after treatment

Study Arms (3)

Severe OSA

Non-severe OSA

Healthy controls

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with obstructive sleep apnea.

You may qualify if:

• Patients with suspected obstructive sleep apnea (OSA) admitted to the sleep center of the respiratory Department of Beijing Chaoyang Hospital, Capital Medical University.
• Volunteer to participate in the study and sign an informed consent, and can complete at least 1 year of follow-up.

You may not qualify if:

• Patients with obstructive sleep apnea who have been treated with impermanent positive pressure ventilation;
• Pregnant or lactating women;
• Patients with severe respiratory failure requiring mechanical ventilation;
• Patients with severe heart, lung, liver, kidney, and central nervous system damage;
• Refuse to participate in follow-up visits and/or take biological samples.

Sponsors & Collaborators

• Capital Medical University: lead

Study Sites (1)

Beijing Chaoyang hospital affiliated to Capital Medical University

Beijing, Beijing Municipality, 100020, China

RECRUITING

MeSH Terms

Conditions

Sleep Apnea, Obstructive

Condition Hierarchy (Ancestors)

Sleep Apnea Syndromes; Apnea; Respiration Disorders; Respiratory Tract Diseases; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases

Central Study Contacts

Zhiling Zhao

CONTACT

+86 186 1280 8859; cysleep@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: January 3, 2024
• First Posted: December 11, 2025
• Study Start: August 7, 2023
• Primary Completion (Estimated): August 7, 2033
• Study Completion (Estimated): August 7, 2033
• Last Updated: December 11, 2025

Record last verified: 2025-04

Locations

CN (1)