Incidence, Treatment and Outcome After Acute Mesenteric Ischemia in the Region of Västra Götaland, 2000-2023.

NCT07274306 | Active Not Recruiting

• 1 other identifier: 2024-04585-01
• Study Type: observational
• Target: 2,446
• Locations: 1 country
• Sites: 2

Brief Summary

The goal of this retrospective observational study is to describe the incidence and outcome of patients diagnosed with acute mesenteric ischemia (AMI) in the Västra Götaland region of Sweden between 2000-2023. The main questions it aims to answer are:

• What was the observed incidence and outcome, and how did it change during the time period?
• How did socioeconomic factors influence incidence and outcome of AMI?
• What main surgical approaches were selected for these patients?
• What was the distribution of anticoagulant use in the cohort, and what effect did the introduction of new oral anticoagulants (NOAC) have on incidence and mortality in AMI?
• What was the prevalence of Short Bowel Syndrome (SBS) after surgical intervention? Participants were obtained from the regional diagnosis registry. Additional datapoints were obtained from the Swedish statistics bureau and pharmaceutical registers.

Conditions

Mesenteric Artery Ischemia

Keywords

Acute mesenteric ischemia; Mesenteric ischemia; Intestinal ischemia; Population-based cohort; Epidemiology; Incidence; Mortality; Mesenteric arterial occlusion; Sweden / Västra Götaland

Outcome Measures

Primary Outcomes (2)

• Incidence of acute mesenteric ischemia

  Annual incidence rate of acute mesenteric ischemia per 100,000 person-years in the Västra Götaland region.

  Year 2000-2023

• Mortality from acute mesenteric ischemia

  All-cause mortality within up to 1 year of AMI diagnosis.

  30 days, 90 days, 1 year.

Secondary Outcomes (5)

• Temporal trends in incidence and mortality

  Year 2000-2023

• Socioeconomic determinants of incidence and outcome

  Year 2000-2023

• Surgical management strategy

  Year 2000-2023

• Prevalence of Short Bowel Syndrome (SBS)

  Within 1 year of surgical intervention

• Anticoagulant use patterns

  At AMI diagnosis; trends from 2000-2023

Study Arms (1)

VG Region patients with AMI diagnosis 2000-2023

A cohort of all patients who were discharged with the diagnosis acute mesenteric ischemia (ICD-10: K55.0 or K55.9) in the Västra Götaland region of Sweden between 2000-01-01 and 2023-12-31.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Inhabitants of the Västra Götaland region in Sweden.

You may qualify if:

• all patients discharged from hospital with acute mesenteric ischemia (ICD K55.0 and K55.9)

Sponsors & Collaborators

• Sahlgrenska University Hospital: lead
• Gothia Forum - Center for Clinical Trial: collaborator
• Göteborg University: collaborator

Study Sites (2)

Sahlgrenska hospital/Östra hospital

Gothenburg, Västra Götaland County, 41685, Sweden

Location

Sahlgrenska University Hospital

Gothenburg, Sweden

Location

MeSH Terms

Conditions

Mesenteric Ischemia

Condition Hierarchy (Ancestors)

Intestinal Diseases; Gastrointestinal Diseases; Digestive System Diseases; Peritoneal Diseases; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, PhD

Study Record Dates

• First Submitted: November 27, 2025
• First Posted: December 10, 2025
• Study Start: February 24, 2025
• Primary Completion: December 1, 2025
• Study Completion: January 1, 2026
• Last Updated: December 10, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

SE (2)