Remote Ischemic Conditioning in Patients Undergoing Primary Percutaneous Coronary Intervention

NCT07272408 | Completed

• 1 other identifier: 40-2022
• Study Type: interventional
• Target: 2
• Locations: 1 country
• Sites: 1

Brief Summary

This study aimed to detect the effects of remote ischemic conditioning on infarct size, global contractility, morbidity, mortality, and renal function in patients undergoing primary percutaneous coronary intervention.

Conditions

Remote; Ischemic Conditioning; Primary Percutaneous Coronary Intervention

Outcome Measures

Primary Outcomes (1)

• Cardiac death

  Incidence of cardiac death was recorded.

  1 month post-procedure

Secondary Outcomes (4)

• Hospitalization for heart failure

  1 month post-procedure

• Contrast induced nephropathy

  1 month post-procedure

• Incidence of adverse events

  1 month post-procedure

• Renal impairment

  1 month post-procedure

Study Arms (2)

Remote ischemic conditioning

EXPERIMENTAL

Remote ischemic conditioning (RIC) was applied to those patients.

Procedure: Remote ischemic conditioning

Normal primary percutaneous coronary intervention

ACTIVE COMPARATOR

Patients followed the standard primary percutaneous coronary intervention pathway.

Procedure: Normal primary percutaneous coronary intervention

Interventions

Remote ischemic conditioning PROCEDURE

Remote ischemic conditioning (RIC) was applied to those patients.

Remote ischemic conditioning

Normal primary percutaneous coronary intervention PROCEDURE

Patients followed the standard primary percutaneous coronary intervention pathway.

Normal primary percutaneous coronary intervention

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age more than 18 and less than 75 years old.
• Both sexes.
• Patients with new ST-segment elevation at the J-point in V1:V6 leads with the cut-point: ≥ 1mm other than leads V2-V3 where the following cut-points apply: ≥ 2mm in men ≥ 40 years; ≥ 2.5mm in men \< 40 years, or ≥ 1.5mm in women regardless of age.
• Patients with new left bundle branch block (LBBB).

You may not qualify if:

• ST-segment elevation myocardial infarction (STEMI) with cardiogenic shock.
• Severe comorbidities (uncontrolled hypertension, morbid obesity, recent cerebrovascular stroke, respiratory failure, sepsis, and stage 4 \& 5 malignancy).
• End-stage renal disease on hemodialysis.
• Previous coronary artery bypass graft surgery (CABG).
• Myocardial infarct within the previous 30 days.
• Multi-vessel coronary artery disease.
• Failure of culprit vessel recanalization.
• Conditions precluding use of remote conditioning ie: paresis of upper limb.
• Life expectancy of less than 1 year due to a non-cardiac pathology.
• Patients who receive nephrotoxic drugs such as non-steroidal anti-inflammatory drugs and aminoglycosides.

Sponsors & Collaborators

• Helwan University: lead

Study Sites (1)

Helwan University

Helwan, 11795, Egypt

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident of Cardiology, Helwan University, Helwan, Egypt

Study Record Dates

• First Submitted: November 26, 2025
• First Posted: December 9, 2025
• Study Start: September 1, 2022
• Primary Completion: December 30, 2023
• Study Completion: December 30, 2023
• Last Updated: December 9, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author.

Locations

EG (1)