HIIT Versus MICT in COPD: Effects on Oxygenation, Pulmonary Function, and Strength

NCT07109687 | Not Yet Recruiting

• 1 other identifier: BSV-000021
• Study Type: interventional
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

Chronic Obstructive Pulmonary Disease (COPD) is a progressive condition marked by airflow limitation and chronic inflammation, leading to reduced exercise capacity, peripheral muscle dysfunction, and dyspnea. High-Intensity Interval Training (HIIT) may offer a promising alternative for patients with low exercise tolerance; however, evidence on its effectiveness remains limited. This study aims to compare the effects of HIIT and Moderate-Intensity Continuous Training (MICT) on muscle oxygenation, pulmonary function, exercise capacity, and peripheral muscle strength in individuals with COPD. Participants will undergo an 8-week exercise program, twice weekly. HIIT will consist of 1-minute intervals at 90% and 30-40% of peak workload, while MICT will involve continuous cycling at 65% of peak workload. Outcomes will be assessed at baseline, week 4, and week 8. Data will be analyzed using SPSS. This study seeks to determine the more effective training modality to optimize COPD rehabilitation.

Conditions

Chronic Obstructive Pulmonary Disease (COPD)

Keywords

High Intensity Interval Training; Exercise Training; Muscle Oxygenation

Outcome Measures

Primary Outcomes (1)

• Peripheral and Respiratory Muscle Oxygenation

  Muscle oxygenation will be measured using Near-Infrared Spectroscopy from the dominant quadriceps (peripheral) and 7th intercostal space (respiratory) during rest, warm-up, exercise, recovery phases, and 5 minutes post-exercise. Parameters include SmO₂\_basal, SmO₂\_max, SmO₂\_min, SmO₂\_maxrec, ∆SmO₂\_max, SmO₂\_deox, SmO₂\_reoxy, and ∆SmO₂\_maxrec.

  at the baseline, at the 4th week, at the end of the 8th week.

Secondary Outcomes (8)

• Pulmonary Function test

  at the baseline, at the 4th week, at the end of the 8th week.

• Functional Exercise Capacity

  at the baseline, at the 4th week, at the end of the 8th week.

• Dyspnea

  at the baseline, at the 4th week, at the end of the 8th week.

• Upper extremity Muscle Strength

  at the baseline, at the 4th week, at the end of the 8th week.

• Activities of Daily Living

  at the baseline, at the 4th week, at the end of the 8th week.

Study Arms (2)

Control Group

ACTIVE COMPARATOR

standard aerobic exercise will apply in moderate intensity continuous training.

Other: MICT

interval exercise group

EXPERIMENTAL

Other: HIIT GROUP

Interventions

HIIT GROUP OTHER

Participants will perform a 31-minute protocol on a cycle ergometer consisting of 1-minute high-intensity intervals at 90% of peak workload (W peak) and low-intensity intervals at 30-40% of W peak, twice a week for 8 weeks.

interval exercise group

MICT OTHER

Moderate intensity continous exercise

Control Group

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosed with Chronic Obstructive Pulmonary Disease (COPD),
• GOLD stage 2, 3, or 4,
• Willing to participate in the study,
• Aged between 40 and 80 years,
• Clinically stable (no significant deterioration in the current medical condition, no recent initiation of a new treatment, and no complications requiring hospitalization).

You may not qualify if:

• Presence of visual, auditory, vestibular, cognitive, or neurological impairments that may affect balance,
• Any orthopedic, neurological, or cardiac conditions that may interfere with study participation or exercise,
• Presence of serious chronic diseases such as congestive heart failure, coronary artery disease, or chronic renal failure,
• Conditions that may cause physical limitations (e.g., limb amputation, significant musculoskeletal disorders, or postural abnormalities such as kyphosis or lordosis).

Sponsors & Collaborators

• Aynur Demirel: lead
• Antalya Bilim University: collaborator
• Hacettepe University: collaborator

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Fulsen Bozkus, MD., Prof.

  Sağlık Bilimleri University Antalya Health Application and Research Center

  STUDY DIRECTOR

• Aynur Demirel, PT, PhD, Assoc. Prof.

  Hacettepe University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Aynur Demirel, PT, PhD, Assoc. Prof.

CONTACT

+903051576168; aynur.demirel@hacettepe.edu.tr

Irem Suzen, PT MsC

CONTACT

+905393260706; irem.suzen@antalya.edu.tr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
• Masking Details: Statistical Analyzer will be masked.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: PT, PhD, Assoc. Prof.

Model Details: HIIT or MICT will be applied in patients with COPD groups.

Study Record Dates

• First Submitted: July 16, 2025
• First Posted: August 7, 2025
• Study Start: October 1, 2025
• Primary Completion (Estimated): March 1, 2027
• Study Completion (Estimated): June 1, 2027
• Last Updated: August 7, 2025

Record last verified: 2025-07