To Evaluate Post Operative Pain Using Two Different Kind of Sealers in Obturation of Teeth With Symptomatic Irreversible Pulpitis During Second Visit When the Patient is Painless

NCT07266974 | Not Yet Recruiting Phase 2

• 1 other identifier: DJ/277/25
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this randomized clinical trial is to evaluate pain after root canal treatment using two different kinds of sealers during obturation in 60 healthy , male and female patients ages between 18 to 40 years. The main aims is to systematically evaluate and compare post-operative pain levels in patients undergoing root canal treatment with two different types of endodontic sealers: AH plus (SEAL APEX) and bio ceramic sealer(META) • By identifying the sealer that leads to the least discomfort, this research could significantly enhance patient care, minimize recovery time, and improve overall treatment success in endodontics. Participants in both groups will be given a visual analogue scale(VAS) to measure the pain level after the root canal treatment has been completed. They will measure pain levels at 12, 24 and 48 hours. All information will be recorded on proforma and compared.

Conditions

Irreversible Pulpitis; Post Operative Pain, Acute

Keywords

post operative pain; bioceramic sealer; irreversible pulpitis

Outcome Measures

Primary Outcomes (1)

• post operative pain in both sealer groups after obturation

  Post-operative pain levels will be measured and compared in both groups using Visual Analogue Scale (VAS) Patients were asked to rate their pain on a numerical scale from 0 to 10, where 0 indicated no pain and 10 indicated the worst pain imaginable. For interpretation, pain intensity was categorized as follows: 1-3: Mild pain 4-6: Moderate pain 7-10: Severe pain

  6 months

Study Arms (2)

Group A , AH plus sealer , Group B ( bioceramic sealer)

ACTIVE COMPARATOR

patients in group A will recieve AH plus sealer and in group B shall recieve bioceramic sealer for obturation during root canal treatment

Drug: bioceramic sealer

Group A , (AH plus sealer ) , Group B ( bioceramic sealer)

ACTIVE COMPARATOR

patients in Group A will recieve Ah plus sealer for obturation and patients in group B shall recieve bioceramic sealer for obtration during root canal treatment second visit

Drug: AH-Plus Epoxy Resin Sealer

Interventions

AH-Plus Epoxy Resin Sealer DRUG

AH plus sealer is an epoxy resin based sealer that is biocompatible with good sealing ability

Group A , (AH plus sealer ) , Group B ( bioceramic sealer)

bioceramic sealer DRUG

MTA based sealers,biocermic sealers are biocompatible, safe to use

Group A , AH plus sealer , Group B ( bioceramic sealer)

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Patients ranging from 18 to 40 years.
• Patients whose teeth have been diagnosed with Symptomatic irreversible pulpitis.
• maxillary and mandibular teeth.
• A normal periapical condition on radiograph, or one with little to no periodontal ligament (PDL) space widening, confirming the normal periapical state.
• Teeth that can be restored.
• Teeth with healthy periodontium.

You may not qualify if:

• Non-restorable teeth.
• Patients with poor health whose systemic complications could change the course of treatment.
• Teeth with immature roots.
• Teeth with periapical lesions or apical periodontitis.
• Teeth with Necrotic pulp.

Sponsors & Collaborators

• Jaweria Gul Keyani: lead

Study Sites (1)

Margalla Institute of Health Sciences, Gulraiz phase III Quaid e azam Avenue, Rawalpindi

Rawalpindi, Punjab Province, 46000, Pakistan

Location

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Central Study Contacts

Jaweria gul keyani

CONTACT

+ 92 3312931111; jaweriagulkeyani@gmail.com

Dr lubna Pasha

CONTACT

+92 333 9499959

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Post Graduate Trainee

Study Record Dates

• First Submitted: November 24, 2025
• First Posted: December 5, 2025
• Study Start: April 1, 2026
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): October 1, 2026
• Last Updated: January 8, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)