Carotid Doppler Screening for Subclinical Atherosclerosis in Diabetic CKD Patients.

NCT07266220 | Not Yet Recruiting

• 1 other identifier: AUN-IM-CKD-CAROTID-2025
• Study Type: observational
• Target: 96
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study is being done at Assiut University to look for early signs of hardening of the arteries (atherosclerosis) in people who have both diabetes and chronic kidney disease (CKD). Many patients with these conditions are at higher risk of heart disease and stroke, but the disease can develop quietly without symptoms. We will use a safe, non-invasive test called carotid Doppler ultrasound, which uses sound waves to check the neck arteries (carotid arteries) for early changes. The goal is to see how often these early changes occur in patients with diabetes and CKD, and whether the findings relate to their kidney function, blood sugar control, and other health factors. This research may help doctors detect vascular problems earlier and guide better prevention strategies for patients at risk.

Conditions

Diabetes Mellitus, Type 2; Chronic Kidney Disease; Atherosclerosis

Outcome Measures

Primary Outcomes (1)

• Prevalence of subclinical carotid atherosclerosis (defined as increased carotid intima-media thickness and/or carotid plaque detected by carotid Doppler ultrasound).

  Carotid Doppler ultrasound will be performed once at study entry to measure carotid intima-media thickness and detect the presence of carotid plaque. The percentage of patients with subclinical carotid atherosclerosis will be estimated among adults with type 2 diabetes mellitus and stage 3 chronic kidney disease.

  At baseline (single assessment at enrollment).

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients with type 2 diabetes mellitus and stage 3 chronic kidney disease recruited from the nephrology and internal medicine outpatient clinics and inpatient wards of Assiut University Hospitals.

1. Age≥18years. 2. Diagnosis of type 2 diabetes mellitus (per treating physician or ADA criteria). 3. CKDstage3:eGFR30-59mL/min/1.73 m² on at least two measurements ≥3 months apart OR established diagnosis in medical record. 4. Clinically stable (no AKI, no hospitalization for cardiovascular event in past 3 months). 5. Ableandwilling to provide informed consent.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• Abdallah Ali Mohammed: lead

MeSH Terms

Conditions

Diabetes Mellitus, Type 2; Renal Insufficiency, Chronic; Atherosclerosis

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Resident Physician, Internal Medicine

Study Record Dates

• First Submitted: November 22, 2025
• First Posted: December 5, 2025
• Study Start: January 1, 2026
• Primary Completion (Estimated): March 1, 2027
• Study Completion (Estimated): April 1, 2027
• Last Updated: December 5, 2025

Record last verified: 2025-12