NCT07264686|Active Not RecruitingPhase 2
Ulcer Plants: Highly Accessible Plant Antiseptics for Use in Remote Areas of PNG - Second Trial
UP2025
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Sponsor study identifier
interventional
222
1 country
1
Study Start
November 3, 2025
Actual (reported)Primary Completion
November 21, 2025
Actual (reported)Study Completion
September 30, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Small cutaneous ulcers are common in Papua New Guinea but are normally left untreated due to lack of easy access to basic medicines. The goal of this clinical trial is to test the efficacy of a readily available antibacterial plant medicine called Pterocarpus indicus comparing healing outcomes to control arms receiving Savlon antiseptic cream and no treatment. Participants with cutaneous ulcers less than 1cm in diameter will be randomized to receive topical treatment with a plant medicines, Savlon cream or no treatment treatment and followed up at day 7 and 14 to assess ulcer healing and ulcer surface area.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
September 30, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 3, 2025
Actual (reported)November 21, 2025
Actual (reported)November 24, 2025
Actual (reported)December 4, 2025
Actual (reported)September 30, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
wound healing
A wound diameter reduction of more than 25% measured by the eKare wound imaging system.
2 weeks
Description: P. indicus sap exhibits antibacterial activivity agaisnt S. pyogenes, a pàthogen associated with cutaneous ulcer disease in Papau New Guinea. The sap has been tested using the Ames test for mutagenesis, and found to be non-mutagenic; testing was carried out by toxicology service provider Gentronix, UK (results available separately on request).
Common over the counter antiseptic cream
Description: P. indicus sap exhibits antibacterial activivity agaisnt S. pyogenes, a pàthogen associated with cutaneous ulcer disease in Papau New Guinea. The sap has been tested using the Ames test for mutagenesis, and found to be non-mutagenic; testing was carried out by toxicology service provider Gentronix, UK (results available separately on request).
Active Comparator: Savlon antiseptic cream (cetrimide with chlorhexidine digluconate)
Vunapope Hospital, and surrounding area
Kokopo, EAST NEW Britan, Papua New Guinea
First Submitted
November 24, 2025
First Posted
December 4, 2025
Study Start
November 3, 2025
Actual (reported)no intevention control
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Primary Completion
November 21, 2025
Actual (reported)Study Completion
September 30, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
July 16, 2026
Record last verified: 2026-07
Data will be made available upon request within a reasonable time-frame.
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Source: ClinicalTrials.gov.
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