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Study Arms (5)

Ficus septica exudate

EXPERIMENTAL

Other: Ficus septica exudate (antiseptic plant exudates)

Pterocarpus indicus exudate

EXPERIMENTAL

Other: Pterocarpus indicus exudate

Curcuma longa aqueous extract

EXPERIMENTAL

Other: Curcuma longa aqueous extract

Savlon antiseptic cream (cetrimide with chlorhexidine digluconate )

Interventions

Ficus septica exudate (antiseptic plant exudates)Other

F. septica sap contains the antibacterial alkaloid ficuseptine which exhibits activivity agaisnt S. pyogenes and H. ducreyi, two pàthogens associated with cutaneous ulcer disease in Papau New Guinea. The sap has been tested using the Ames test for mutagenesis, and found to be non-mutagenic; testing was carried out by toxicology service provider Gentronix, UK (results available separately on request).

Ficus septica exudate

Pterocarpus indicus exudateOther

Eligibility Criteria

Age5 Years - 17 Years

Sexall

Healthy VolunteersNo

Age GroupsChild (0-17)

You may qualify if:

Infected skin ulcer suspected with one or more predominantly moist ulcerative skin lesions of less than 1 cm diameter in greatest dimension and larger than 0.5cm in largest dimension with a predominantly moist surface, occurring below the knee.
Accepted and signed informed consent by a legal guardian (relative or teacher)

MeSH Terms

Conditions

Skin UlcerLymphoproliferative Disorders

Interventions

Cetrimoniumchlorhexidine gluconate

Condition Hierarchy (Ancestors)

Skin DiseasesSkin and Connective Tissue DiseasesLymphatic DiseasesHemic and Lymphatic DiseasesImmunoproliferative DisordersImmune System Diseases

Intervention Hierarchy (Ancestors)

Cetrimonium CompoundsTrimethyl Ammonium Compounds

Study Design

Study Type

interventional

Phase

phase 2

Allocation

RANDOMIZED

Masking

DOUBLE

Who Masked

INVESTIGATOR, OUTCOMES ASSESSOR

Purpose

TREATMENT

Intervention Model

PARALLEL

Model Details: The study we propose is an evaluator-blinded, randomized clinical trial to compare the effects of topical application of three traditional medicine plant saps compared to Savlon cream or no treatment: (A) Ficus septica plant sap (50μl) applied topically at baseline, day 3 and day 7. (B) Pterocarpus indicus plant sap (50μl) applied topically at baseline, day 3 and day 7. (C) Curcuma longa plant sap (50μl) applied topically at baseline, day 3 and day 7. (D) Savlon cream (200mg) applied topically at baseline, day 3 and day 7. (E) No treatment.

Sponsor Type

OTHER

Responsible Party

SPONSOR

Ulcer Plants: Highly Accessible Plant Antiseptics for Use in Remote Areas of PNG

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

Primary Completion

Study Completion

First Submitted

First Posted

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Study Arms (5)

Ficus septica exudate

Pterocarpus indicus exudate

Curcuma longa aqueous extract

Savlon antiseptic cream (cetrimide with chlorhexidine digluconate )

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Intervention Hierarchy (Ancestors)

Enrollment

Study Design

Study Record Dates

Control

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

Primary Completion

Study Completion

First Submitted

First Posted

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Study Arms (5)

Ficus septica exudate

Pterocarpus indicus exudate

Curcuma longa aqueous extract

Savlon antiseptic cream (cetrimide with chlorhexidine digluconate )

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Intervention Hierarchy (Ancestors)

Enrollment

Study Design

Study Record Dates

Control

You may not qualify if:

Data Sharing

Source record

Locations