LA Strain in Predicting Early Complication in STEMI After PPCI

NCT07263282 | Not Yet Recruiting DMC

• 1 other identifier: left atrial strain in STEMI
• Study Type: observational
• Target: 135
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study To evaluate the predictive value of left atrial strain for in-hospital outcomes in patients with ST-segment elevation myocardial infarction undergoing PPCI. The main questions it aims to answer are: Is low parameters of left atrial strain associated early complication ? What is the correlation between LA strain parameters and conventional echocardiographic indices of left ventricular systolic and diastolic function ? Is there more affection to LA strain in certain territory over the others ? What is the correlation between LA strain and LA volume index across infarct territories ? Does LA strain Correlate with TAPSE and PASP to evaluate right-heart interactions ?

Conditions

ST Elevation (STEMI) Myocardial Infarction

Keywords

strain in STEMI

Outcome Measures

Primary Outcomes (1)

• the predictive value of left atrial strain for detecting incidence of in-hospital outcomes in patients with ST-segment elevation myocardial infarction undergoing primary PCI.

  To evaluate the predictive value of left atrial strain for hospitalized patients with ST-segment elevation myocardial infarction undergoing primary PCI as regarding * All-cause in-hospital mortality * New/worsening heart failure requiring IV therapy or ICU care * Cardiogenic shock (requiring inotropes or mechanical support) * Sustained ventricular arrhythmia (VT/VF)

  up to one week

Secondary Outcomes (4)

• correlation with other parameters

  up to one week

• LA strain across different territories

  up to one week

• LA stain vs LAVI

  up to one week

• LA strain and right side

  up to one week

Study Arms (3)

group normal strain

group normal parameters of LA strain by 2D echocardiography

Other: 2D echocardiography

group low strain

group low parameters of LA strain by 2D echocardiography

Other: 2D echocardiography

group control

control group to provide reference for normal parameters of LA strain for age by 2D echocardiography

Other: 2D echocardiography

Interventions

2D echocardiography OTHER

LA strain by 2D echocardiographic speckle tracking analysis

group control; group low strain; group normal strain

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients diagnosed with ST-segment elevation myocardial infarction and Underwent successful primary percutaneous coronary intervention and control group to provide baseline parameters for comparing LA strain and other echocardiographic parameters

You may qualify if:

• Adults aged ≥18 years.
• Diagnosed with ST-segment elevation myocardial infarction (STEMI) according to current ESC/AHA criteria
• Underwent successful primary percutaneous coronary intervention (PPCI) within 12 hours of symptom onset.
• Sinus rhythm on admission .
• Trans thoracic echocardiography (TTE) performed within 48 hours of admission with adequate image quality for speckle-tracking analysis.

You may not qualify if:

• Previous myocardial infarction or prior PCI/CABG.
• Patients known to have atrial fibrillation or other sustained supraventricular arrhythmias.
• Significant valvular heart disease (severe stenosis or regurgitation).
• Congenital heart disease or cardiomyopathy (hypertrophic, dilated, restrictive).
• Poor echocardiographic window preventing LA strain analysis .
• Mechanical complications (e.g., papillary muscle rupture, VSD, free wall rupture).
• Prior cardiac surgery or known structural lesions that preventing reliable LA measurement.
• patient presenting with killip class III or IV from the start

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Assiut university

Asyut, Egypt

Location

Related Publications (14)

• Badano LP, Kolias TJ, Muraru D, Abraham TP, Aurigemma G, Edvardsen T, D'Hooge J, Donal E, Fraser AG, Marwick T, Mertens L, Popescu BA, Sengupta PP, Lancellotti P, Thomas JD, Voigt JU; Industry representatives; Reviewers: This document was reviewed by members of the 2016-2018 EACVI Scientific Documents Committee. Standardization of left atrial, right ventricular, and right atrial deformation imaging using two-dimensional speckle tracking echocardiography: a consensus document of the EACVI/ASE/Industry Task Force to standardize deformation imaging. Eur Heart J Cardiovasc Imaging. 2018 Jun 1;19(6):591-600. doi: 10.1093/ehjci/jey042.

  PMID: 29596561 RESULT

• Nagueh SF, Smiseth OA, Appleton CP, Byrd BF 3rd, Dokainish H, Edvardsen T, Flachskampf FA, Gillebert TC, Klein AL, Lancellotti P, Marino P, Oh JK, Popescu BA, Waggoner AD. Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2016 Apr;29(4):277-314. doi: 10.1016/j.echo.2016.01.011. No abstract available.

  PMID: 27037982 RESULT

• Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, Flachskampf FA, Foster E, Goldstein SA, Kuznetsova T, Lancellotti P, Muraru D, Picard MH, Rietzschel ER, Rudski L, Spencer KT, Tsang W, Voigt JU. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2015 Jan;28(1):1-39.e14. doi: 10.1016/j.echo.2014.10.003.

  PMID: 25559473 RESULT

• Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, Caforio ALP, Crea F, Goudevenos JA, Halvorsen S, Hindricks G, Kastrati A, Lenzen MJ, Prescott E, Roffi M, Valgimigli M, Varenhorst C, Vranckx P, Widimsky P; ESC Scientific Document Group. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018 Jan 7;39(2):119-177. doi: 10.1093/eurheartj/ehx393. No abstract available.

  PMID: 28886621 RESULT

• Ahmeti A, Bytyci FS, Bielecka-Dabrowa A, Bytyci I, Henein MY. Prognostic value of left atrial volume index in acute coronary syndrome: A systematic review and meta-analysis. Clin Physiol Funct Imaging. 2021 Mar;41(2):128-135. doi: 10.1111/cpf.12689. Epub 2021 Jan 12.

  PMID: 33372377 RESULT

• Wu H, Wang H, Wang X, Xu L, Wu J. Myocardial strain combined with clinical risk factors in the prediction of in-hospital heart failure among patients with ST-segment elevation myocardial infarction. Clin Radiol. 2024 Nov;79(11):e1304-e1311. doi: 10.1016/j.crad.2024.07.016. Epub 2024 Jul 26.

  PMID: 39191561 RESULT

• Chu AA, Wu TT, Zhang L, Zhang Z. The prognostic value of left atrial and left ventricular strain in patients after ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention. Cardiol J. 2021;28(5):678-689. doi: 10.5603/CJ.a2020.0010. Epub 2020 Feb 10.

  PMID: 32037499 RESULT

• Svartstein AW, Lassen MH, Skaarup KG, Grove GL, Vyff F, Ravnkilde K, Pedersen S, Galatius S, Modin D, Biering-Sorensen T. Predictive value of left atrial strain in relation to atrial fibrillation following acute myocardial infarction. Int J Cardiol. 2022 Oct 1;364:52-59. doi: 10.1016/j.ijcard.2022.05.026. Epub 2022 May 14.

  PMID: 35577164 RESULT

• Nagueh SF, Khan SU. Left Atrial Strain for Assessment of Left Ventricular Diastolic Function: Focus on Populations With Normal LVEF. JACC Cardiovasc Imaging. 2023 May;16(5):691-707. doi: 10.1016/j.jcmg.2022.10.011. Epub 2023 Jan 11.

  PMID: 36752445 RESULT

• Robinson S, Ring L, Oxborough D, Harkness A, Bennett S, Rana B, Sutaria N, Lo Giudice F, Shun-Shin M, Paton M, Duncan R, Willis J, Colebourn C, Bassindale G, Gatenby K, Belham M, Cole G, Augustine D, Smiseth OA. The assessment of left ventricular diastolic function: guidance and recommendations from the British Society of Echocardiography. Echo Res Pract. 2024 Jun 3;11(1):16. doi: 10.1186/s44156-024-00051-2.

  PMID: 38825710 RESULT

• Li R, Sun F, Piao S, He X, Li R, Xu L, Song G, Cong J. Left Atrial Strain and Compliance Correlate with Diastolic Dysfunction Grades and Complications during Pre-eclampsia: A Speckle-Tracking Echocardiography Study. Ultrasound Med Biol. 2021 Dec;47(12):3411-3419. doi: 10.1016/j.ultrasmedbio.2021.08.003. Epub 2021 Aug 27.

  PMID: 34456083 RESULT

• Lenselink C, Ricken KWLM, Groot HE, de Bruijne TJ, Hendriks T, van der Harst P, Voors AA, Lipsic E. Incidence and predictors of heart failure with reduced and preserved ejection fraction after ST-elevation myocardial infarction in the contemporary era of early percutaneous coronary intervention. Eur J Heart Fail. 2024 May;26(5):1142-1149. doi: 10.1002/ejhf.3225. Epub 2024 Apr 4.

  PMID: 38576163 RESULT

• Zhang L, Liu Z, Zhu Y, Wu M, Huang H, Yang W, Peng K, Zeng J. Development and validation of a prognostic model for predicting post-discharge mortality risk in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). J Cardiothorac Surg. 2024 Mar 30;19(1):163. doi: 10.1186/s13019-024-02665-3.

  PMID: 38555468 RESULT

• Abe T, Olanipekun T, Adedinsewo D, Ogunmoroti O, Udongwo N, Effoe V, Rice B, Onuorah I, Ghali JK, Mehta PK, Michos ED. Trends and Outcomes of ST-Segment-Elevation Myocardial Infarction Among Young Women in the United States. J Am Heart Assoc. 2023 Mar 7;12(5):e026811. doi: 10.1161/JAHA.122.026811. Epub 2023 Feb 27.

  PMID: 36847058 RESULT

MeSH Terms

Conditions

ST Elevation Myocardial Infarction; Myocardial Infarction

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Officials

• Doaa A Fouad, Professor

  Assiut University

  PRINCIPAL INVESTIGATOR

• Magdy I Algowhary, Assistant Professor

  Assiut University

  PRINCIPAL INVESTIGATOR

• Ahmed G Bakry, Assistant Professor

  South Valley University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ahmed Y Dandrawy, medical doctor

CONTACT

+201013086863; ahmed_youssef200@yahoo.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principle investigator

Study Record Dates

• First Submitted: November 16, 2025
• First Posted: December 4, 2025
• Study Start: December 1, 2025
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): February 1, 2027
• Last Updated: December 12, 2025

Record last verified: 2025-12

Locations

EG (1)