Correlation Between Triglyceride Glucose Index and Myocardial Injury Assessed by Cardiac Magnetic Resonance Imaging (CMR) in Patients With STEMI

NCT07261514 | Completed

• 1 other identifier: 2025QG-TyG index
• Study Type: observational
• Target: 674
• Locations: 1 country
• Sites: 1

Brief Summary

This research aim is to investigate the correlation between triglyceride glucose index (TyG index) and myocardial infarct size, microcirculation obstruction (MVO) and intramyocardial hemorrhage (IMH) assessed by cardiac magnetic resonance imaging (CMR) in patients with ST-segment elevation myocardial infarction (STEMI), and to evaluate its value as a potential predictor of myocardial injury.To further determine the influence of TyG index on the prognosis of STEMI patients after PCI.This cohort included 674 patients with STEMI undergoing primary percutaneous coronary intervention (pPCI). Baseline clinical data were collected and cardiac magnetic resonance imaging was performed approximately 7 days after Acute Myocardial Infarction(AMI). Patients were divided into three groups according to the TyG index , namely high TyG index group, medium TyG index group and low TyG index group. Multiple linear regression, Pearson/Spearman correlation analysis and Logistics regression analysis were used to analyze the correlation between TyG index and myocardial infarct size, microcirculation obstruction and intramyocardial hemorrhage.Eventually, we came to the conclusion that the TyG index was independently associated with severity of myocardial injury after STEMI as assessed by CMR. TyG index is not only an independent predictor of microcirculation disturbance in STEMI patients, but also significantly correlated with poor cardiovascular prognosis. is a powerful marker for stratifying risk of adverse cardiovascular events.

Conditions

ST Elevation (STEMI) Myocardial Infarction

Keywords

ST-segment elevation Myocardial Infarction; triglyceride glucose index; Cardiac magnetic resonance; myocardial infarct size; intramyocardial hemorrhage; microvascular obstruction

Outcome Measures

Primary Outcomes (1)

• major adverse cardiovascular events

  Death , recurrence of myocardial infarction, heart failure after discharge

  4 years after discharge

Secondary Outcomes (3)

• myocardial infarct size

  Cardiac MRI within 7 days after surgery

• Microvascular occlusion

  Cardiac MRI within 7 days after surgery

• Intramyocardial hemorrhage (IMH)

  Cardiac MRI within 7 days after surgery

Study Arms (3)

low TyG index group

Patients with a TyG index below 1.41 were categorized into the low TyG group.

medium TyG index

Patients with a TyG index between 1.41 and 1.96 were categorized into the medium TyG group.

high TyG index group

Patients with a TyG index greater than 1.96 were categorized into the high TyG index group.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

primary PCI-treated patients with acute STEMI

You may qualify if:

• \) patients meet diagnostic criteria for STEMI-"The priority for these patients is the implementation of reperfusion therapy as soon as possible .In the appropriate clinical context,ST-segment elevation (accessed at the J-point) indicates possible acute coronary artery in the following situations:New ST elevation at the J-point in at least two contiguous leads:·≥ 2.5 mm in men under 40years,≥2mm in males 40 years and older,or ≥1.5mmin women relatively less of age in leads V2-V3,and/or ≥1mm in the other leads (in the absence of left ventricular hypertrophy or left bundle branch block) Post-STEMI reperfusion with PCI, diagnosis and treatment strategy in accordance with current diagnosis and treatment standards and guidelines27" and complete pPCI within 48h-"" diagnostic strategy meets current diagnostic criteria and guidelines;2) KillIP\<3 and consent to CMR examination and follow-up observation, and CMR examination is completed within 7 days after surgery. 3) Monitor baseline blood glucose and baseline triglycerides during admission.

You may not qualify if:

• Contraindications of CMR examination, such as implantable cardiac pacemaker, claustrophobia, allergy to gadolinium contrast agent or renal insufficiency; meanwhile, patients with Killip IV cardiac function or unstable clinical condition, as well as patients with valve disease, congenital heart disease, pulmonary hypertension, cardiomyopathy history, persistent atrial fibrillation, etc. affecting cardiac structure and function parameters shall be excluded; Patients with a history of myocardial infarction, coronary artery intervention, or coronary artery bypass grafting were also excluded. Patients with severe hematological diseases, infectious diseases, malignant tumors, liver and kidney failure, mental disorders or intellectual disabilities who could not cooperate with examination and follow-up, or poor or missing MRI images were not included in the study.

Sponsors & Collaborators

• Chinese PLA General Hospital: lead
• Beijing Anzhen Hospital: collaborator
• Beijing Chao Yang Hospital: collaborator
• Second Affiliated Hospital of Nanchang University: collaborator
• First People's Hospital of Yulin: collaborator
• Wuhan Asia Heart Hospital: collaborator
• Zunyi Medical College: collaborator

Study Sites (1)

Chinese PLA General Hospital

Beijing, Beijing Municipality, 100039, China

Location

MeSH Terms

Conditions

ST Elevation Myocardial Infarction; Myocardial Infarction

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Officials

• geng qian

  Chinese PLA General Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Chief Physician

Study Record Dates

• First Submitted: November 22, 2025
• First Posted: December 3, 2025
• Study Start: January 1, 2014
• Primary Completion: December 31, 2023
• Study Completion: May 2, 2024
• Last Updated: December 3, 2025

Record last verified: 2014-01

Locations

CN (1)