Trials Sponsors Conditions Drugs Pricing

Conditions

Intrabony Defect Intrabony Defects in Chronic Periodontitis

Keywords

I-PRF with xenograft

Outcome Measures

Primary Outcomes (1)

Radiographic parameters
• The bone fill after 6 months postoperatively using digital periapical radiography using parallel technique.
6 months after treatment

Secondary Outcomes (4)

Pocket depth (PD)
presurgically, 3 and 6 months interval after treatment
Plaque index (PI)
pre-surgically 3 months and 6 months respectively
Gingival index (GI)
pre-surgically 3 months and 6 months respectively
Clinical attachment level (CAL)
pre-surgically 3 months and 6 months respectively

Study Arms (2)

injectable platelet rich fibrin and xenograft

OTHER

Intrasulcular incisions will be performed buccally and lingually/palatally on the affected tooth and extended one adjacent tooth mesially and distally, using 15c blades. Following mucoperiosteal flap elevation, thorough debridement will be performed using ultrasonic scalers and curettes until defects are clear from any granulation tissue, and the defect morphology will be visually explored and recorded .In the group 2: xenograft (Bovin xenograft) with injectable platelet Rich fibrin (I- PRF) will be applied to the intrabony defect area.

Procedure: injectable platelet rich fibrin and xenograftProcedure: Xenograft alone

xenograft alone

ACTIVE COMPARATOR

Interventions

injectable platelet rich fibrin and xenograftProcedure

Elevation of papilla preservation flap at the site of 3mm infrabony defect ,prepearing the I-PRF which is obtained from the patients own blood , centrifuged at 700 rpm in 3 min and mixed with xenograft than placed at the defect area after removal all the granulation tissue follow up after 3 and 6 months intervals

injectable platelet rich fibrin and xenograftxenograft alone

Xenograft aloneProcedure

Eligibility Criteria

Age30 Years - 55 Years

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64)

You may qualify if:

Patient should have localized Periodontitis stage III grade B with pocket depth ≥ 6mm; indicated for periodontal surgery
Patient's agreement to the surgical procedure and clinical trial.

Sponsors & Collaborators

Al-Azhar University
Otherlead

Study Sites (2)

Faculty of Dental Medicine for Girls, Al- Azhar University

Cairo, Cairo Governorate, Egypt

Ola Jamal

Cairo, Cairo Governorate, Egypt

MeSH Terms

Interventions

Transplantation, Heterologous

Intervention Hierarchy (Ancestors)

TransplantationSurgical Procedures, Operative

Study Officials

Eatemad Ahmed Shoreibah A Shoreibah, Professor
Al-Azhar University
STUDY CHAIR

Study Design

Study Type: interventional
Phase: not applicable
Allocation: RANDOMIZED
Masking: NONE
Purpose: TREATMENT
Intervention Model: PARALLEL
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Oral Medicine, Periodontology, Oral Diagnosis and Radiology Department Faculty of Dental Medicine for Girls Al-Azhar University

Study Record Dates

First Submitted

August 21, 2025

First Posted

December 3, 2025

Study Start

February 17, 2025

Actual (reported)

Primary Completion

February 18, 2025

Treatment of Intrabony Defect in Patient With Periodontitis Stage III by Using I-PRF and Xenograft

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

Primary Completion

First Submitted

First Posted

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (4)

Study Arms (2)

injectable platelet rich fibrin and xenograft

xenograft alone

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (2)

MeSH Terms

Interventions

Intervention Hierarchy (Ancestors)

Study Officials

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

Primary Completion

First Submitted

First Posted

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (4)

Study Arms (2)

injectable platelet rich fibrin and xenograft

xenograft alone

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (2)

MeSH Terms

Interventions

Intervention Hierarchy (Ancestors)

Study Officials

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations