Trials Sponsors Conditions Drugs Pricing

Conditions

Hopeless Teeth

Keywords

dental implantErythropoietinXenograft

Outcome Measures

Primary Outcomes (1)

Buccal bone thickness.
by Cone Beam Computed Tomography (CBCT) in mm
1 year follow up period

Secondary Outcomes (7)

Crestal bone loss
1 year follow up period
Soft tissue thickness.
1 year follow up period
The pink esthetic score (PES)
1 year follow up period
Success and survival criteria
1 year follow up period
Bleeding on probing (BOP)
1 year follow up period
+2 more secondary outcomes

Study Arms (2)

Group A (Test)

EXPERIMENTAL

Immediate implant placement with Xenograft mixed with Erythropoietin

Combination Product: Erythropoietin (EPO) with xenograft

Group B (Control)

ACTIVE COMPARATOR

Immediate implant placement with Xenograft alone

Other: Xenograft alone

Interventions

Erythropoietin (EPO) with xenograftCombination product

After atraumatic extraction of the non-restorable tooth, Implant will be placed palatal and apical to osteotomy with at least 2mm gap junction between implant and buccal bone which will be grafted with xenograft and erythropoietin.

Group A (Test)

Xenograft aloneOther

After atraumatic extraction of the non-restorable tooth, implant will be placed palatal and apical to osteotomy with at least 2mm gap junction between implant and buccal bone which will be grafted with xenograft alone.

Eligibility Criteria

Age18 Years+

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

Adult (≥18 years) with non-restorable maxillary teeth in the esthetic zone (upper right second premolar to upper left second premolar).
Intact with thin labial plate of bone (≤1mm).

Sponsors & Collaborators

Cairo University
Otherlead

Study Sites (1)

Faculty of dentistry, Cairo university

Giza, Egypt

Cairo UniversityCONTACT(+202)23634965 dentmail@dentistry.cu.edu.eg

kholoud Sobhy Eldeeb, Master degree holderCONTACT

Related Publications (1)

Fettouh AIA, Ghallab NA, Ghaffar KA, Mina NA, Abdelmalak MS, Abdelrahman AAG, Shemais NM. Bone dimensional changes after flapless immediate implant placement with and without bone grafting: Randomized clinical trial. Clin Implant Dent Relat Res. 2023 Apr;25(2):271-283. doi: 10.1111/cid.13178. Epub 2023 Jan 3.
PMID: 36596471BACKGROUND

MeSH Terms

Interventions

ErythropoietinTransplantation, Heterologous

Intervention Hierarchy (Ancestors)

Colony-Stimulating FactorsGlycoproteinsGlycoconjugatesCarbohydratesHematopoietic Cell Growth FactorsCytokinesIntercellular Signaling Peptides and ProteinsPeptidesAmino Acids, Peptides, and ProteinsProteinsBiological FactorsTransplantation

Study Officials

Noha ghallab, PHD
Professor of Oral Medicine and Periodontology, Faculty of Dentistry, Cairo University.
STUDY DIRECTOR
Manar El Zanaty, PHD
lecturer of periodontology
STUDY CHAIR

Central Study Contacts

kholoud El Deeb, Master degree holder

CONTACT

(+20)1113211914 kholoud.eldeeb@dentistry.cu.edu.eg

Study Design

Study Type: interventional
Phase: not applicable
Allocation: RANDOMIZED
Masking: DOUBLE
Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
Purpose: TREATMENT
Intervention Model: PARALLEL
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: assistant lecturer at future university in egypt

Study Record Dates

First Submitted

September 11, 2024

First Posted

September 19, 2024

Study Start

September 14, 2024

Estimated (date passed)

This estimate has passed. The registry has not confirmed an actual date for this milestone.

Primary Completion

Xenograft with or Without Erythropoietin in Immediate Dental Implant

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

Study Start

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (7)

Study Arms (2)

Group A (Test)

Group B (Control)

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (1)

MeSH Terms

Interventions

Intervention Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

Study Start

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (7)

Study Arms (2)

Group A (Test)

Group B (Control)

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (1)

MeSH Terms

Interventions

Intervention Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations