Association Between Preoperative Health and Functional Status and Postoperative Complications in Elderly Patients

NCT07259837 | Completed

• 1 other identifier: PLAGH - SCALE
• Study Type: observational
• Target: 8,751
• Locations: 1 country
• Sites: 1

Brief Summary

Using prospectively collected clinical data from the Chinese Perioperative Database of Elderly Patients, this study retrospectively analyzed patients aged ≥65 years who underwent elective non-cardiac, non-neurosurgical procedures under general anesthesia between April 2020 and April 2022. The study examined the associations between various preoperative health and functional status assessment tools and the occurrence of cardiovascular and cerebrovascular complications within 30 days after surgery, aiming to compare the clinical value of different assessment instruments.

Conditions

Functional Status; Postoperative Complications; Older Adults (65 Years and Older)

Keywords

Functional status; Quality of life; Major Adverse Cardiac and Cerebrovascular Events; Older adults

Outcome Measures

Primary Outcomes (1)

• The primary outcome was the occurrence of MACCE within 30 days after surgery.

  The primary outcome was the occurrence of MACCE within 30 days after surgery, defined as any of the following: stroke, myocardial infarction, angina pectoris, congestive heart failure, cardiac arrest, or all-cause mortality.\[33\] Postoperative complications were systematically assessed on days 1-5, 7, and 30, and continued until discharge. For discharged patients, outcomes were recorded via telephone follow-up, with diagnoses from the treating hospital. For MACCE, postoperative medical records of hospitalized patients were thoroughly reviewed according to the follow-up schedule, including serial measurements of serum myocardial injury biomarkers, electrocardiograms, echocardiograms, coronary angiography findings, postoperative progress notes, consultation records, and expert diagnostic evaluations.

  Within 30 days after surgery.

Study Arms (1)

A retrospective cohort study based on prospectively collected data.

Patients were divided into the MACCE group and the non-MACCE group according to the occurrence of major adverse cardiac and cerebrovascular events within 30 days after surgery.

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients were interviewed one day before surgery and completed a comprehensive preoperative functional status and quality of life assessment, which included the Basic Activities of Daily Living (BADL), Instrumental Activities of Daily Living (IADL), EuroQol Five-Dimension Five-Level (EQ-5D-5L), Metabolic Equivalent of Task (MET), and FRAIL scale.

You may qualify if:

• Aged ≥65 years;
• Scheduled for elective non-cardiac, non-neurosurgical procedures;
• Consented to undergo preoperative functional status and quality of life assessments.

You may not qualify if:

• Had severe dementia, language disorders, significant hearing or visual impairments, or were in a coma;
• Had Mini-Mental State Examination (MMSE) scores below the established educational thresholds: \<18 for illiterate individuals, \<21 for those with primary education (≤6 years), and \<25 for those with secondary education or higher (\>6 years);
• Underwent local anesthesia or monitored anesthesia care;
• Had an operative time ≤30 minutes;
• Incompleted all the designated functional status and quality of life assessments.

Sponsors & Collaborators

• Chinese PLA General Hospital: lead

Study Sites (1)

Chinese PLA General Hospital

Beijing, Beijing Municipality, 100853, China

Location

MeSH Terms

Conditions

Postoperative Complications

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Deputy Chief of administration, Anesthesiology

Study Record Dates

• First Submitted: November 21, 2025
• First Posted: December 2, 2025
• Study Start: April 1, 2020
• Primary Completion: April 30, 2022
• Study Completion: May 31, 2022
• Last Updated: December 9, 2025

Record last verified: 2025-12

Locations

CN (1)