Comparison of Efficacy of Betamethasone Gel With Lidocaine Gel in Prevention of Post Endotracheal Intubation Sore Throat.

NCT07256834 | Not Yet Recruiting Phase 1

• 1 other identifier: F.2-81/2025-GENL/429/JPMC
• Study Type: interventional
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this clinical trial is to compare the incidence of postoperative sore throat in adult patients of either gender belonging to ASA I or II ,undergoing endotracheal intubation using betamethasone gel versus lidocaine gel. It aims to determine 1: Difference in efficacy of Betamethasone gel and lidocaine gel in prevention of post operative sore throat after endotracheal intubation. Patients will be assessed for the presence of a sore throat at 6 hours and 24 hours postoperatively. The severity of the sore throat will be graded using the Post-Operative Sore Throat (POST) score.

Conditions

Post Operative Sore Throat at 6hrs and 24hrs After Endotracheal Intubation

Outcome Measures

Primary Outcomes (1)

• Post operative sore throat

  Comparing presence and grading of sore throat in both arms after endotracheal intubation.

  Sore throat after endotracheal intubation at 6 hrs and 24hrs post operatively. Sample completion in 2 weeks

Study Arms (2)

Group A receiving betamethasone gel during endotracheal intubation

ACTIVE COMPARATOR

Group A patients, before induction of anesthesia, endotracheal tube will be lubricated with 2.5ml of 0.05% Betamethasone dipropionate gel, from distal end of cuff to 15cm mark on endotracheal tube

Drug: Betamethasone dipropionate 0.05%

Group B receiving lidocaine gel during endotracheal intubation

ACTIVE COMPARATOR

Group B patients, before induction of anesthesia, endotracheal tube will be lubricated with 2.5ml of 2% Lidocaine gel, from distal end of cuff to 15cm mark on endotracheal tube

Drug: Lidocaine hydrochloride 2%

Interventions

Betamethasone dipropionate 0.05% DRUG

It is corticosteroid indicated for relief of inflammatory and pruritic manifestation

Group A receiving betamethasone gel during endotracheal intubation

Lidocaine hydrochloride 2% DRUG

It is amide local anesthetic used for lubrication and pain prevention as topical anesthetic regimen

Group B receiving lidocaine gel during endotracheal intubation

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Patients aged 18-60 years
• Either gender
• ASA I to II
• Patients planned for elective surgery under general anesthesia not lasting more than 4 hours.

You may not qualify if:

• Patients requiring more than 2 attempts for successful intubation
• Patients undergoing surgeries of oral cavity or pharynx
• Mallampati Score of 3 or 4
• Patients with upper respiratory tract infection
• Patients already taking steroids
• Use of nasogastric tube perioperatively

Sponsors & Collaborators

• Jinnah Postgraduate Medical Centre: lead

MeSH Terms

Interventions

Lidocaine

Intervention Hierarchy (Ancestors)

Acetanilides; Anilides; Amides; Organic Chemicals; Aniline Compounds; Amines

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 20, 2025
• First Posted: December 1, 2025
• Study Start: November 22, 2025
• Primary Completion: December 6, 2025
• Study Completion: December 6, 2025
• Last Updated: December 1, 2025

Record last verified: 2025-11