BPIT 5-Week Multi-Site Study: Movement Efficiency, Mobility & Neuromuscular Adaptation

NCT07256717 | Recruiting

• 2 other identifiers: BPIT-MULTI-2025-001MACREB-BPIT-2025-014
• Study Type: interventional
• Target: 369
• Locations: 2 countries
• Sites: 10

Brief Summary

This prospective, multi-site, single-arm interventional study evaluates the 5-Line Principle of Balanced Progressive Intensity Training (BPIT) over 5 weeks in healthy adults aged 18-65 years. All participants receive supervised BPIT sessions (3-5 per week) progressing through five intensity lines defined by anatomical landmarks and ground reaction force: Ground-Based (Low) Knee-Level (Low-Moderate) Standing (Moderate) Head-Level (Moderate-High) Plyometric (High-Impact) The study aims to quantify improvements in functional movement efficiency, joint mobility, postural control, strength adaptation, and heart-rate variability while monitoring safety and individual overload indicators.

Conditions

Physical Fitness

Keywords

Balanced Progressive Intensity Training; BPIT; 5-Line Principle; Movement Efficiency; Heart Rate Variability; Postural Control; Strength Training; Exercise Intervention; Neuromuscular Adaptation

Outcome Measures

Primary Outcomes (1)

• Movement Efficiency Score (MES, 0-10)

  Change from baseline in the proprietary Movement Efficiency Score (MES), a validated composite metric of biomechanical function, movement quality, and postural alignment (derived from MMSx Flaw Checklist, visual/video analysis, and functional mapping).

  Baseline (Week 0) and end of study (Week 5)

Secondary Outcomes (4)

• Range of Motion (ROM)

  Baseline and Week 5

• VAS Pain Score

  Baseline and Week 5

• Strength Index

  Baseline and Week 5

• Mobility Limitation (%)

  Baseline and Week 5

Other Outcomes (1)

• Heart Rate Variability (HRV - RMSSD)

  Baseline and Week 5

Study Arms (1)

BPIT 5-Line Training Group

EXPERIMENTAL

All participants receive the 5-week Balanced Progressive Intensity Training (BPIT) program using the 5-Line Principle (ground-based → knee-level → standing → head-level → plyometric) under supervised sessions 3-5 times per week.

Behavioral: Balanced Progressive Intensity Training (BPIT) 5-Line Method

Interventions

Balanced Progressive Intensity Training (BPIT) 5-Line Method BEHAVIORAL

5-week supervised progressive training using the BPIT 5-Line framework developed by Dr. Neeraj Mehta.

BPIT 5-Line Training Group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged 18-65 years Generally healthy with regular physical activity history (at least 1-2 sessions per week for the past 3 months) Able to commit to 3-5 supervised training sessions per week for 5 weeks Willing and able to provide written informed consent Cleared by pre-screening (no acute injury, no contraindications)

You may not qualify if:

• Acute musculoskeletal injury within the past 3 months Known cardiovascular, metabolic, or orthopaedic conditions that contraindicate exercise Pregnancy or planning pregnancy Use of medications or supplements that significantly affect muscle recovery or performance (e.g., corticosteroids, anabolic agents) Inability to follow the BPIT protocol or attend required sessions

Sponsors & Collaborators

• MMSx Authority Institute for Movement Mechanics & Biomechanics Research Inc.: lead
• BodyGNTX Fitness Institute: collaborator
• GFFI Fitness Academy: collaborator
• Indian Institute of Kinesiology and Biomechanics Science (IIKBS): collaborator
• Bureau of Fitness Standards (BFS): collaborator
• Active India Health & Fitness Trust (AIHFT): collaborator
• Body Mechanic Chain of Gyms: collaborator
• Shri Mahaveer Ortho Clinic: collaborator
• Regain Fitness Zone: collaborator
• MMSx Authority Biomechanics Department: collaborator

Study Sites (10)

BodyGNTX Fitness Institute

Columbus, Ohio, 43220, United States

RECRUITING

MMSx Authority Biomechanics Department

Powell, Ohio, 43065, United States

RECRUITING

MMSx AUTHORITY INSTITUTE FOR MOVEMENT MECHANICS & BIOMECHANICS RESEARCH (COORDINATING CENTER)

Powell, Ohio, 43065, United States

RECRUITING

Indian Institute of Kinesiology & Biomechanics Science (IIKBS)

Burhānpur, Madhya Pradesh, 450331, India

RECRUITING

Shri Mahaveer Ortho Clinic

Delhi, National Capital Territory of Delhi, 110032, India

RECRUITING

GFFI Fitness Academy

New Delhi, National Capital Territory of Delhi, 110026, India

RECRUITING

Active India Health & Fitness Trust (AIHFT)

New Delhi, National Capital Territory of Delhi, 110063, India

RECRUITING

Body Mechanics Gym P Ltd

New Delhi, National Capital Territory of Delhi, 110092, India

RECRUITING

Regain Fitness Zone

Greater Noida, Uttar Pardesh, 201310, India

RECRUITING

GFFI Fitness Academy

Agra, Uttar Pradesh, 282005, India

RECRUITING

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Masking Details: Single-arm prospective interventional study
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 18, 2025
• First Posted: December 1, 2025
• Study Start: October 10, 2025
• Primary Completion: February 15, 2026
• Study Completion: February 25, 2026
• Last Updated: December 16, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

US (3); IN (7)