Investigation of the Impact of Medications Used in COVID-19 Treatment and COVID-19 Vaccine on Hearing

NCT07254442 | Completed

• 2 other identifiers: 2021/61-181919B012102481
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

Investigation of the Impact of Medications Used in COVID-19 Treatment and COVID-19 Vaccine on Hearing

Conditions

Hearing; COVID - 19; Ototoxicity

Outcome Measures

Primary Outcomes (3)

• Pure tone and high frequency hearing thresholds

  December, 2021-February 2022

• Transient evoked otoacoustic emissions - Signal/noise ratio

  December, 2021-February 2022

• Distortion product otoacoustic emissions- signal/noise ratio

  December, 2021-February 2022

Study Arms (3)

Control group

Group that has not had Covid-19

Diagnostic Test: Hearing tests

Medication Group

The group that had Covid-19 and used medication

Diagnostic Test: Hearing tests

Non-medication group

The group that had Covid-19 and did not use medication

Diagnostic Test: Hearing tests

Interventions

Hearing tests DIAGNOSTIC_TEST

Participants' pure tone thresholds, high frequency thresholds, and otoacoustic emissions measurements were evaluated.

Control group; Medication Group; Non-medication group

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

1. Those who have had COVID-19 and are taking medication 2. Those who have had COVID-19 and are not taking medication 3. Healthy individuals who have not had COVID-19

You may qualify if:

• Age between 18 and 35 For the Medication group: Having had COVID-19 and using COVID-19 medications For the Non-Medication group: Having had COVID-19 and not using COVID-19 medications For the Control group: Having never had COVID-19

You may not qualify if:

• Previously diagnosed with hearing loss Use of ototoxic medications other than those specified Pathology detected during tympanometric evaluation or otoscopic examination Chronic disease Family history of hearing loss History of meningitis Neurological disorders Acute or chronic ear infection Admission to intensive care

Sponsors & Collaborators

• Zonguldak Bulent Ecevit University: lead

Study Sites (1)

Biruni University

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

COVID-19; Ototoxicity

Interventions

Hearing Tests

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Ear Diseases; Otorhinolaryngologic Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Drug-Related Side Effects and Adverse Reactions; Chemically-Induced Disorders; Radiation Injuries; Wounds and Injuries

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Otological; Diagnostic Techniques and Procedures; Diagnosis

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Audiologist, Lecturer

Study Record Dates

• First Submitted: September 26, 2025
• First Posted: November 28, 2025
• Study Start: December 1, 2021
• Primary Completion: February 1, 2022
• Study Completion: March 1, 2022
• Last Updated: November 28, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)