Hypnosis to Improve Well-beings of Critically Ill Patients and Prevent Post-intensive Care Syndrome
HypnoPICS
1 other identifier
interventional
150
1 country
2
Brief Summary
The goal of this clinical trial is to evaluate the effectiveness of a hypnosis intervention in improving well-being at day 28 of an ICU stay. The main question it aims to answer is :
- Does Hypnosis intervention at ICU discharge and on day 7 and 14 on the wards if the patient remains in the hospital, improve wellbeing at 28 days ? Researchers will compare discharged ICU patients who received standard post-discharge care to discharged ICU patients who received standard post-discharge care and hypnosis intervention on discharge and 7 and 14days after if they are still in the hospital, to see if hypnosis can improve their wellbeing. Participants will receive a hypnosis session on the day of ICU discharge, a second session seven days post-discharge and a third session at day 14 if they are still in the hospital.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Mar 2026
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 14, 2025
CompletedFirst Posted
Study publicly available on registry
November 28, 2025
CompletedStudy Start
First participant enrolled
March 16, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
March 1, 2027
May 4, 2026
April 1, 2026
12 months
November 14, 2025
April 28, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Wellbeing at day 28 post intensive care unit discharge
ESAS scale (Edmonton Symptom Assessment System) with a range from 0 to 100. Higher scores means worse wellbeing.
Day 28 post intensive care unit discharge
Secondary Outcomes (7)
Immediate wellbeing following a hypnosis session
Day 1 (Day of discharge from ICU), day 7, day 14
PDI - Peritraumatic distress inventory
day 28 post ICU discharge
PHQ-9 - Patient Health Questionnaire-9
Day 28 post intensive care unit discharge and 3 months post intensive care
GAD-7 - Generalized Anxiety Disorder-7
at day 28 and 3 months post ICU discharge
IES-R (Impact of event Scale)
3 months post intensive care unit discharge. Higher score means more PTSD symptoms.
- +2 more secondary outcomes
Study Arms (2)
Hypnosis group
EXPERIMENTALParticipants in the intervention group will receive a hypnosis session on the day of discharge, a second session seven days post-discharge, and a third session on day 14 if they are still in the hospital. Trained professionals will conduct the hypnosis sessions following a standardized protocol, designed by the study team for critically ill patients.
Control group
NO INTERVENTIONParticipants in the control group will receive standard post-discharge care, which includes mobilization, nutrition, pain control, and family engagement and empowerment, without any hypnosis intervention.
Interventions
the hypnosis will be tailored to each patient. Key elements will include relaxation (to mitigate anxiety and stress and help the patient feel more comfortable, secure, and competent), reassociation techniques (to help the patient reconnect with their body, promoting a sense of embodiment and presence), and safe place (to introduce a safe and calming place to instill a sense of control and competence, aiding in emotional stabilization and fostering a sense of safety and well-being).
Eligibility Criteria
You may qualify if:
- On Mechanical Ventilation for at least 2 days
- Able to give informed consent as documented by signature
- French speaking
You may not qualify if:
- Refusal of the patient
- Patient transferred from another ICU
- Patient is planned for a withdrawal of care or is actively dying
- Glasgow coma scale (GCS) \<15 on ICU discharge
- Patient presenting with delirium (detected by CAM-ICU) on ICU discharge
- Patient hospitalized for traumatic brain injury
- Patient is in jail
- Patient hospitalized for more than 28 days in the ICU
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- COEN Matteolead
Study Sites (2)
University Hospital of Geneva
Geneva, 1205, Switzerland
Hôpitaux Neuchâtelois
Neuchâtel, Switzerland
Related Publications (2)
Schmidt B, Schneider J, Deffner T, Rosendahl J. Hypnotic suggestions of safety improve well-being in non-invasively ventilated patients in the intensive care unit. Intensive Care Med. 2021 Apr;47(4):485-486. doi: 10.1007/s00134-021-06364-8. Epub 2021 Feb 16. No abstract available.
PMID: 33590259RESULTSpiegel D, Cardena E. New uses of hypnosis in the treatment of posttraumatic stress disorder. J Clin Psychiatry. 1990 Oct;51 Suppl:39-43; discussion 44-6.
PMID: 2211565RESULT
Related Links
MeSH Terms
Conditions
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Hannah Wozniak, Medical Doctor
University Hospital, Geneva
- PRINCIPAL INVESTIGATOR
Matteo Coen, MD, PHD
University Hospital, Geneva
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Dr. med. PD. PhD
Study Record Dates
First Submitted
November 14, 2025
First Posted
November 28, 2025
Study Start
March 16, 2026
Primary Completion (Estimated)
March 1, 2027
Study Completion (Estimated)
March 1, 2027
Last Updated
May 4, 2026
Record last verified: 2026-04