NCT07247617

Brief Summary

To compare the efficacy, safety, success rate, operative time, and cost-effectiveness of flexible ureteroscopy versus semirigid ureteroscopy in the management of upper ureteric stones smaller than 2 cm. The investigators' main concern in this study is Upper third ureteric stones to determine which cases can be treated with Semi-Rigid Ureteroscopy, and which one needs flexible ureteroscopy. This depends on several factors:

  1. 1.Division of the upper third of the ureter
  2. 2.Stone size
  3. 3.Stone impaction
  4. 4.Surgeon experience
  5. 5.Anesthesia
  6. 6.Ureteric dilatation above the stone
  7. 7.Mini endoscopy

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
100

participants targeted

Target at P50-P75 for not_applicable

Timeline
8mo left

Started Oct 2025

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress48%
Oct 2025Jan 2027

First Submitted

Initial submission to the registry

September 22, 2025

Completed
9 days until next milestone

Study Start

First participant enrolled

October 1, 2025

Completed
2 months until next milestone

First Posted

Study publicly available on registry

November 25, 2025

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2026

Expected
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2027

Last Updated

November 25, 2025

Status Verified

October 1, 2025

Enrollment Period

1 year

First QC Date

September 22, 2025

Last Update Submit

November 22, 2025

Conditions

Ureteric StoneFlexible UreteroscopyUpper Urinary Tract Stones

Outcome Measures

Primary Outcomes (1)

  • - Stone-free rate at 3 months duration

    3 months

Study Arms (2)

Flexible Ureteroscopy

ACTIVE COMPARATOR
Procedure: Flexible URS

Semi-Rigid Ureteroscopy

EXPERIMENTAL
Procedure: Semi-Rigid URS

Interventions

Flexible URSPROCEDURE

Flexible URS

Flexible Ureteroscopy
Semi-Rigid URSPROCEDURE

Semi-Rigid URS

Semi-Rigid Ureteroscopy

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patients ≥18 years
  • upper ureteric stone
  • ≤20 mm

You may not qualify if:

  • Associated renal stones
  • Any contraindications to Anesthesia

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Assiut Hospital

Asyut, Asyut Governorate, Egypt

RECRUITING

Related Publications (1)

  • Granholm L, Svendgaard N. Hydrocephalus following traumatic head injuries. Scand J Rehabil Med. 1972;4(1):31-4. No abstract available.

    PMID: 4220357RESULT

MeSH Terms

Conditions

UreterolithiasisUrinary Calculi

Condition Hierarchy (Ancestors)

Ureteral DiseasesUrologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesUrolithiasisMale Urogenital DiseasesCalculiPathological Conditions, AnatomicalPathological Conditions, Signs and Symptoms

Central Study Contacts

Omar Ahmed Hamada Ali

CONTACT

+201092868286omarahmedhamada74@gmail.com

Mohamed Ragab Abdallah, Doctor

CONTACT

+201066237580mohammedurology1290@gmail.com

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Urology Resident

Study Record Dates

First Submitted

September 22, 2025

First Posted

November 25, 2025

Study Start

October 1, 2025

Primary Completion (Estimated)

October 1, 2026

Study Completion (Estimated)

January 1, 2027

Last Updated

November 25, 2025

Record last verified: 2025-10

Locations

EG(1)