IPP-PSP Block vs. SPSIPB in Breast Surgery

NCT07246720 | Not Yet Recruiting

• 1 other identifier: 2025/16-9
• Study Type: interventional
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective, randomized clinical study aims to compare the analgesic efficacy of the interpectoral-pectoserratus plane block and the serratus posterior superior intercostal plane block for postoperative pain management in patients undergoing breast cancer surgery. Both techniques are ultrasound-guided regional anesthesia methods targeting different interfascial planes of the thoracic wall. The study will evaluate postoperative pain scores, opioid consumption, Quality of recovery and potential complications. The findings are expected to contribute to optimizing regional anesthesia strategies for enhanced recovery and improved analgesia following breast cancer surgery.

Conditions

Postoperative Acute Pain; Breast Cancer; Regional Anesthesia

Keywords

Interpectoral-Pectoserratus Plane Block; Serratus Posterior Superior Intercostal Plane Block; Breast Cancer Surgery; Opioid Consumption; Pain Management

Outcome Measures

Primary Outcomes (1)

• Cumulative opioid consumption

  Cumulative opioid consumption in the first 24 postoperative hours after the completion of the surgical procedure

  in the first 24 hours after completion of the surgical procedure

Secondary Outcomes (2)

• Postsurgical Quality of Recovery measured by the Quality of Recovery questionnaire

  first day after surgery

• Number of episodes of postoperative pain

  In the first 24 hours after completion of the surgical procedure

Study Arms (2)

Group IPP-PSP

ACTIVE COMPARATOR

Interpectoral-Pectoserratus Plane Block

Procedure: Interpectoral-Pectoserratus Plane Block

Group SPSIPB

ACTIVE COMPARATOR

Serratus Posterior Superior Intercostal Plane Block

Procedure: Serratus Posterior Superior Intercostal Plane Block

Interventions

Interpectoral-Pectoserratus Plane Block PROCEDURE

Ultrasound-guided injection between pectoralis major-minor and pectoralis minor-serratus anterior planes.

Group IPP-PSP

Serratus Posterior Superior Intercostal Plane Block PROCEDURE

Ultrasound-guided injection between the serratus posterior superior muscle and the intercostal muscles.

Group SPSIPB

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• years of age
• ASA I-II-III risk groups
• Patients with informed consent
• Patients undergoing breast cancer surgery

You may not qualify if:

• ASA ≥ IV
• History of allergy to local anesthetics
• Known coagulation disorders
• Infection near the insertion site
• Chronic analgesic use
• Patients with diabetes mellitus and those receiving neoadjuvant chemotherapy (due to potential impairment of pain sensation)
• Body mass index \>30
• Dementia or confusion
• Lack of cooperation

Sponsors & Collaborators

• Zonguldak Bulent Ecevit University: lead

Study Sites (1)

Zonguladk Bulent ecevit University

Zonguldak, Kozlu, 67600, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pain, Postoperative; Breast Neoplasms; Agnosia

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms; Neoplasms by Site; Neoplasms; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases; Perceptual Disorders; Neurobehavioral Manifestations; Nervous System Diseases

Central Study Contacts

çağdaş baytar, MD

CONTACT

+905542255960; cagdasbaytar31@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: CARE PROVIDER, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: medical doctor

Study Record Dates

• First Submitted: November 17, 2025
• First Posted: November 24, 2025
• Study Start: November 15, 2025
• Primary Completion (Estimated): May 31, 2026
• Study Completion (Estimated): June 30, 2026
• Last Updated: November 24, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)