Biofilm Formation and Antifungal Resistance in Candida Species

NCT07245563 | Not Yet Recruiting

• 1 other identifier: candida species identification
• Study Type: observational
• Target: 300
• Locations: 0 countries
• Sites: N/A

Brief Summary

1. 1.To determine the susceptibility pattern of our local isolated Candida strains which is essential for optimal management of fungal infection.
2. 2.Detection of biofilm formation by conventional and molecular methods
3. 3.Comparison between C. albicans and non-albicans in the prevalence of biofilm formation and biofilm -forming genes
4. 4.Find the association between antifungal resistance and biofilm formation in candida strains isolated from patients
5. 5.Determination of clinical factors associated with occurrence of infections.

Conditions

Candida Infection

Outcome Measures

Primary Outcomes (2)

• To asses the prevalence of candida species as a cause of infection in patient in hematology intinsive care unit

  1 year

• To asses the prevalence of genes responsible for biofilm formation in different candida species

  1 year

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

patients admitted to hematology intensive care

You may qualify if:

• Eligible participants in the study were those with invasive infection and had one or more of this criteria :
• oSuppressed general body immunity.
• oSuppressed local body immunity as a result of trauma or invasive procedures.
• oResistant to antibiotic therapy.
• oNegative samples for bacterial examination and culture.
• Critical life threatening infect

You may not qualify if:

• Patients who received antifungal therapy within 3 days prior to sample collection.
• Resistant to antibiotic therapy.

Sponsors & Collaborators

• Assiut University: lead

Biospecimen

Retention: SAMPLES WITH DNA

sputum,urine and blood

MeSH Terms

Conditions

Candidiasis

Condition Hierarchy (Ancestors)

Mycoses; Bacterial Infections and Mycoses; Infections

Central Study Contacts

mennat-allah khaled abdelhady

CONTACT

00201151387078; roserena2@gmail.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: demonstrator at microbiology department at Assiut university

Study Record Dates

• First Submitted: October 2, 2025
• First Posted: November 24, 2025
• Study Start: December 20, 2025
• Primary Completion (Estimated): September 20, 2026
• Study Completion (Estimated): October 12, 2026
• Last Updated: November 24, 2025

Record last verified: 2025-11