Kinetics of Serum β-D-glucan During Peritonitis With Candida in Resuscitation

NCT03140748 | Completed

• 1 other identifier: PI2016_843_0036
• Study Type: interventional
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

Intraabdominal fungal infections with Candida are constantly increasing. Their diagnosis and treatment is difficult. Morbidity and mortality are high. Β-D-Glucan has been proposed as a marker of systemic fungal infection in candidemia. Moreover, its kinetics is associated with therapeutic success. On the other hand, there are no data on intraabdominal infections that are much more frequent. The objective of the study is to evaluate the initial levels of β-D-glucan and its daily kinetics during the treatment of fungal peritonitis in resuscitation compared to a control group with a yeast-free peritonitis.

Conditions

Peritonitis Infectious; Candida Infection

Outcome Measures

Primary Outcomes (1)

• Blood determination of serum β-D-glucan kinetics in patients with peritonitis

  Blood determination of serum β-D-glucan kinetics in patients with peritonitis

  28 days

Study Arms (2)

Patients with fungal peritonitis

OTHER

Other: To evaluate the initial levels and kinetics of serum β-D-glucan

Patients with peritonitis without yeast

OTHER

Other: To evaluate the initial levels and kinetics of serum β-D-glucan

Interventions

To evaluate the initial levels and kinetics of serum β-D-glucan OTHER

To evaluate the initial levels and kinetics of serum β-D-glucan during fungal peritonitis compared to a control group of yeast-free peritonitis

Patients with fungal peritonitis; Patients with peritonitis without yeast

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Major Patient (age ≥ 18 years)
• Community or associated peritonitis, operated and hospitalized in resuscitation
• Affiliation to a social security scheme

You may not qualify if:

• Allergy known to echinocandins
• Dying Patient
• Limitation of care
• Predictable duration of follow-up ≤ 10 days
• Transfusion within 3 months
• Patient minor, patient under guardianship or curatorship

Sponsors & Collaborators

• Centre Hospitalier Universitaire, Amiens: lead

Study Sites (1)

CHU Amiens Picardie

Amiens, Picardie, 80054, France

Location

Related Publications (1)

• Dupont H, Malaquin S, Villeret L, Macq PY, Ammenouche N, Tinturier F, Diouf M, Rumbach M, Chouaki T. Is ss-d-glucan Relevant for the Diagnosis and Follow-Up of Intensive Care Patients with Yeast-Complicated Intra-Abdominal Infection? J Fungi (Basel). 2022 May 6;8(5):487. doi: 10.3390/jof8050487.

  PMID: 35628743 RESULT

MeSH Terms

Conditions

Candidiasis

Condition Hierarchy (Ancestors)

Mycoses; Bacterial Infections and Mycoses; Infections

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: SCREENING
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 14, 2017
• First Posted: May 4, 2017
• Study Start: May 1, 2018
• Primary Completion: August 22, 2021
• Study Completion: June 1, 2023
• Last Updated: September 19, 2025

Record last verified: 2025-09

Locations

FR (1)