Balance Evaluation in Adult Hemophilia

NCT07243912 | Completed

• 1 other identifier: YuzuncuYil2025
• Study Type: observational
• Target: 81
• Locations: 1 country
• Sites: 1

Brief Summary

Introduction: Recurrent hemarthrosis in hemophilia can cause deterioration of static and dynamic balance in hemophilia. Studies in AwH report decreased dynamic balance, but consistent results regarding static balance are lacking. The causes of the decrease in dynamic balance and its associated parameters have been under explored. Aim: To investigate static and dynamic balance in AwH compared to healthy controls and factors such as joint health, physical activity and kinesiophobia that may affect dynamic balance. Methods: This cross-sectional controlled study included 41 AwH and 40 healthy controlled, totally 81 man and study groups determined as Hemophilia Group (HG) and Control Group (CG). Static (Static Stability Test) and dynamic balance (Limits of Stability Test (LoS) Test) were assessed Pro-kin Technobody Posturographic Platform; physical activity level with International Physical Activity Questionnaire (IPAQ) for all groups. Joint health and kinesiophobia were assessed with Hemophilia Joint Health Score and Tampa Scale for Kinesiophobia (TSK) for HG, respectively. Participants' age, height and weight were questioned in both groups, as well as type and severity of hemophilia, type of treatment, and work/job status in HG.

Conditions

Postural Balance

Keywords

hemophilia; postural balance; musculoskeletal disease; physical activity; kinesiophobia

Outcome Measures

Primary Outcomes (1)

• Static and Dynamic Balance Assessment

  Static and dynamic balance assessments were performed using the Pro-kin Technobody Posturographic Platform (Pro-kin 212, Technobody s.r.l., Dalmine, 21044 Bergamo, Italy). Static balance was assessed using the "Static Stability Test." This test is based on the subject's oscillations on the force platform, assessing the movement of the center of pressure, and the trunk sensor measuring trunk oscillation. Dynamic balance will be assessed using the Limits of Stability test. For the LoS test, a medium difficulty level (20 levels) will be selected from the 5-10-20-30-40 difficulty levels. Participants will be asked to orient their center of gravity toward eight directional targets for a limited time.

  From enrollment to at 4 weeks

Secondary Outcomes (3)

• Joint Health

  From enrollment to 4 weeks

• Physical Activity Level

  From enrollment to 4 weeks

• Kinesiophobia

  From enrollment to 4 weeks

Study Arms (2)

Control Group

Healthy individual

Diagnostic Test: Postural balance assessment

Hemophilia Group

Adults with Hemophilia

Diagnostic Test: Postural balance assessment

Interventions

Postural balance assessment DIAGNOSTIC_TEST

Static and dynamic balance was analyzed with the posturographic platform.

Control Group; Hemophilia Group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Gender Eligibility Details: Since hemophilia is a hereditary disease seen in males, only males were included in the control group.
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Hemophilia patients and healthy volunteers

You may qualify if:

• Severe or moderate hemophilia A or B

You may not qualify if:

• Diabetus mellitus, hemiplegia, rheumatoid arthritis, Alzheimer's disease, Parkinson's disease, all vestibular system pathologies, lower extremity surgery within the last 6 months, using a walking aid.

Sponsors & Collaborators

• Ayse Merve TAT: lead

Study Sites (1)

Van Yüzüncü Yıl University

Van, Tuşba, 65080, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Hemophilia A; Musculoskeletal Diseases; Motor Activity; Kinesiophobia

Condition Hierarchy (Ancestors)

Blood Coagulation Disorders, Inherited; Blood Coagulation Disorders; Hematologic Diseases; Hemic and Lymphatic Diseases; Coagulation Protein Disorders; Hemorrhagic Disorders; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Behavior; Phobic Disorders; Anxiety Disorders; Mental Disorders

Study Officials

• Ayşe M Tat, Asst Prof

  Yuzuncu Yil University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 7 Days
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: November 14, 2025
• First Posted: November 24, 2025
• Study Start: September 10, 2025
• Primary Completion: October 10, 2025
• Study Completion: October 20, 2025
• Last Updated: November 24, 2025

Record last verified: 2025-11

Locations

TU (1)