SOFA Score with Serum Procalcitonin Versus SOFA Score with Neutrophil/lymphocyte Ratio in Predicting Sepsis and Clinical Outcomes in I.C.U.

NCT06847477 | Not Yet Recruiting

• 1 other identifier: FMASU R24/2025
• Study Type: observational
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

Sepsis remains a critical life-threatening and a healthcare challenge worldwide. Sepsis is implicated in a mortality rate that ranges between 25 - 30% in severe cases and 40-70% in septic shock, also, Post sepsis, lower quality of life was observed among survivors, therefore early prediction and a rapid therapeutic decision, are essential to improve patient outcomes. Different indicators are proposed as predictors but with different sensitivity, specificity, and availability. This study aims to evaluate the efficacy of PCT and SOFA scores versus SOFA and NLR in predicting morbidity and mortality outcomes in sepsis.

Conditions

Sepsis; Critical Illness

Keywords

SOFA score; procalcitonin; neutrophils to lymphocytes ratio

Outcome Measures

Primary Outcomes (1)

• Length of ICU stay

  It includes the total number of days spent in the ICU, calculated from the time of admission to the time of discharge from the ICU or death, whichever comes first. The unit of measurement is days.

  from the time of admission to the time of discharge from the ICU or death up to 40 days from ICU admission

Secondary Outcomes (2)

• 28 days mortality

  From the day of admission at the ICU and up to 28 days.

• Antibiotics used

  From ICU admission to discharge from ICU or death which comes first up to 40 days from admission.

Study Arms (1)

Critically ill patients presented to Surgical and Trauma intensive care

Critically ill patients who are presented to the Surgical and Trauma intensive care unit will be assessed on admission to ICU by SOFA score, procalcitonin, and neutrophils/lymphocytes ratio. then the patients will be followed to measure the length of stay and mortality.

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Critically ill patients presented to Surgical and Trauma intensive care unit

You may qualify if:

• critically ill patients admitted to ICU for surgical or trauma causes.

You may not qualify if:

• Lack of consent

Sponsors & Collaborators

• Ain Shams University: lead

Related Publications (2)

• Kumar R, Kattimani B, Ojha PR, Khasage UJ. Quick Sequential Organ Failure Assessment Score, Lactate, and Neutrophil-Lymphocyte Ratio Help in Diagnosis and Mortality Prediction during Golden Hour of Sepsis in Emergency Department. J Emerg Trauma Shock. 2023 Oct-Dec;16(4):161-166. doi: 10.4103/jets.jets_37_23. Epub 2023 Oct 24.

  PMID: 38292274 BACKGROUND

• Bajic D, Matijasevic J, Andrijevic L, Zaric B, Lalic-Popovic M, Andrijevic I, Todorovic N, Mihajlovic A, Tapavicki B, Ostojic J. Prognostic Role of Monocyte Distribution Width, CRP, Procalcitonin and Lactate as Sepsis Biomarkers in Critically Ill COVID-19 Patients. J Clin Med. 2023 Feb 2;12(3):1197. doi: 10.3390/jcm12031197.

  PMID: 36769843 BACKGROUND

MeSH Terms

Conditions

Sepsis; Critical Illness

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Disease Attributes

Central Study Contacts

wessam zaher selima, MD

CONTACT

0021001958858; w.z.selima@med.asu.edu.eg

Basma sherif Fahmy, MD

CONTACT

0021113151814; Basma@med.asu.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 21, 2025
• First Posted: February 26, 2025
• Study Start: March 1, 2025
• Primary Completion: June 1, 2025
• Study Completion: July 1, 2025
• Last Updated: February 26, 2025

Record last verified: 2025-02