A Community-based Prospective Cohort Study on Metabolic Dysfunction-Associated Fatty Liver Disease in Older Adults: From Metabolic Trajectories to Extrahepatic Outcomes

NCT07241195 | Not Yet Recruiting

• 1 other identifier: SJP20250401
• Study Type: observational
• Target: 20,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

To establish a cohort of elderly fatty liver disease based on the community medical examination population. Through the large-scale cohort study, the risk factors affecting fatty liver in the elderly will be explored in depth from the aspects of lifestyle, environment and genetics, the development pattern and mechanism of fatty liver in the elderly will be analysed, and the health risk assessment system and Chinese standard for fatty liver in the elderly covering cardiovascular risk, risk of hepatic fibrosis and risk of sarcopenia will be established, so as to provide the scientific basis for the precise intervention of fatty liver in the elderly in China.

Conditions

NAFLD and NASH; NAFLD( Non-alcoholic Fatty Liver Disease ); NAFLD Cirrhosis

Outcome Measures

Primary Outcomes (1)

• Incidence of liver fibrosis

  2 years

Secondary Outcomes (2)

• Incidence of cardiovascular disease

  2 years

• Incidence of sarcopenia

  2 years

Study Arms (2)

control group

Observation Group

Lifestyle interventions

Eligibility Criteria

• Age: 65 Years - 100 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

elder people

You may qualify if:

• ① Elderly people aged ≥65 years among permanent residents (living for more than 5 years) in the survey area;
• Imaging diagnosis (ultrasound or FibroScan/FibroTouch) of fatty liver; -③ Voluntary participation in this study and signing an informed consent form.

You may not qualify if:

• ①Major disability, mental illness, major wasting disease, severe cardiac, pulmonary and renal insufficiency;
• Patients with combined primary liver cancer or other types of cancer; -③Patients who have received liver transplant or other organ transplants.

Sponsors & Collaborators

• The Affiliated Hospital of Hangzhou Normal University: lead

MeSH Terms

Conditions

Non-alcoholic Fatty Liver Disease

Condition Hierarchy (Ancestors)

Fatty Liver; Liver Diseases; Digestive System Diseases

Central Study Contacts

Wei Zhang, DR

CONTACT

+8613567135527; zhangwei969696@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 2 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 17, 2025
• First Posted: November 21, 2025
• Study Start: March 12, 2026
• Primary Completion (Estimated): December 31, 2030
• Study Completion (Estimated): December 31, 2030
• Last Updated: November 21, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share