NCT07238491

Brief Summary

Tightness of hamstring muscle is known as a reduction in range of motion accompanied by a sensation of restriction in the posterior aspect of thigh. Numerous reasons can cause it, such as genetic susceptibility, compensatory tightness due to persistent abnormalities, and muscular strain. Tight hamstrings cause a small amount of knee flexion during exercise and require comparatively high quadriceps efforts to offset the hamstrings' passive resistance. This could result in knee joint pain that affects gait and raise the reaction forces at the patellofemoral joint.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
84

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Nov 2025

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

November 14, 2025

Completed
6 days until next milestone

First Posted

Study publicly available on registry

November 20, 2025

Completed
Same day until next milestone

Study Start

First participant enrolled

November 20, 2025

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 28, 2026

Completed
13 days until next milestone

Study Completion

Last participant's last visit for all outcomes

April 10, 2026

Completed
Last Updated

April 15, 2026

Status Verified

November 1, 2025

Enrollment Period

4 months

First QC Date

November 14, 2025

Last Update Submit

April 11, 2026

Conditions

Keywords

virtual realityHamstring tightnessflexibilityMuscle strengthgait parametersyoung adults

Outcome Measures

Primary Outcomes (1)

  • Muscle strength

    Microfit hand-held dynamometer (HHD) will be used for assessment of hamstring muscle strength. Each participant will lie prone on a standard treatment table. In this position, the participant will be instructed to bend their knee to 90° of knee flexion, where the Microfet 2 MMT-Wireless HHD will be placed on the lower leg, and a downward force toward the table will be held for 5s while the participant resists the downward force. The participant will be instructed to use their maximum effort. It will be performed three times, and an average will be recorded.

    5 weeks

Secondary Outcomes (5)

  • Active Knee Extension (AKE) Test

    5 weeks

  • Step length

    5 weeks

  • Stride length

    5 weeks

  • Cadence

    5 weeks

  • Velocity

    5 weeks

Study Arms (2)

Group A (Virtual reality group)

EXPERIMENTAL

Participants will receive virtual reality (VR) in addition to the traditional physical therapy program 2 times/week for 5 weeks.

Device: Virtual realityOther: Traditional physical therapy programme

Group B (control group)

ACTIVE COMPARATOR

Participants will receive a traditional physical therapy program only, 2 times per week for 5 weeks.

Other: Traditional physical therapy programme

Interventions

A five-minute warm-up, thirty minutes of intervention training, and a five-minute cool-down will all be included in each session. Five minutes of stretching and walking were part of the warm-up. Every participant will play five sports games (running, cool-running, catching gift, football, skate) during each session. These gamed can help teenagers to improve their physical strength, endurance, balance, and coordination. Every game lasted Five minutes.

Group A (Virtual reality group)

The exercise programme includes farmer walks, squats, calf raises, stretching exercises, and strengthening activities. The exercises will be performed in one or two sets of 15-20 repetitions, with a 60-second rest in between. The sets, repetitions, and loads will be increased as the participants advance, up to three sets of 60 repetitions for a perceived effort of 70%-80% of 1RM

Group A (Virtual reality group)Group B (control group)

Eligibility Criteria

Age18 Years - 30 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Sedentary adults with tightness of hamstring muscle with the degree of flexion for knee joint more than 20° throughout active knee extension (AKE) test.
  • Their age between 18 and 30 years.
  • BMI less than 30 kg/ m2 .
  • Sedentary lifestyle that includes sitting on the chair for long period of time for minimum 6 hours per day, 5 days/week for 6 months minimally.
  • Participants who did not engaged in a physiotherapy programs in the previous 6 months.
  • Absence of fractures, injuries or medications (such as analgesics or muscle relaxants) that may affect the results of the study.

You may not qualify if:

  • Any neurological diseases (such as; severe disc prolapse and radiating pain).
  • Injury of hamstring in the previous 2 years.
  • History of knee injury.
  • Fracture in lower extremity or the spine.
  • Surgery in the spine.
  • Unequal leg length \> 2cm.
  • Congenital deformity.
  • Orthopedic disorders such as patellofemoral pain syndrome, musculoskeletal pain, psychiatric problem.
  • Any systemic disease, hearing or visual deficits, cognitive, or cardiovascular complications, and pregnancy.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Faculty of physical therapy, Cairo University

Giza, Egypt

Location

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor of physical therapy for surgery, Faculty of physical therapy

Study Record Dates

First Submitted

November 14, 2025

First Posted

November 20, 2025

Study Start

November 20, 2025

Primary Completion

March 28, 2026

Study Completion

April 10, 2026

Last Updated

April 15, 2026

Record last verified: 2025-11

Data Sharing

IPD Sharing
Will share
Shared Documents
STUDY PROTOCOL

Locations