Progression Patterns of Choroidal Venous Alterations

NCT07236671 | Recruiting DMC

• 1 other identifier: 2024-4359
• Study Type: observational
• Target: 250
• Locations: 3 countries
• Sites: 4

Brief Summary

This study is about understanding how a condition called pachychoroid changes over time. Pachychoroid refers to an anatomic choroidal characteristic with abnormally thick choroid or abnormally dilated Haller's vessels. Pachychoroid can range from mild forms which does not cause any problems to more serious ones that might cause vision loss.This study will recruit participants with pachychoroid, to learn more about how this condition develops, how it affects people in the long run, and what factors might make it worse.

Conditions

Pachychoroid Disease

Outcome Measures

Primary Outcomes (1)

• Progression of choroidal venous alterations

  Proportion of eyes demonstrating progression of choroidal venous alterations, defined as either an increase in number of quadrants with pachyvessels or formation of new choroidal anastomoses.

  3 years

Secondary Outcomes (2)

• Incidence of progression of pachychoroid disease manifestation

  3 years

• Risk factors associated with progression of choroidal venous alteration

  3 years

Eligibility Criteria

• Age: 45 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study will aim to recruit 170 participants in Singapore National Eye Centre (SNEC) and 50 participants in National University Hospital, 30 participants from the University of Malaya

You may qualify if:

• Adults aged 45 years or older.
• Presence of pachyvessels on ultra-widefield (UWF) imaging in at least one quadrant.
• Willing to undergo pupil dilation, and protocol-required procedures for both eyes
• Willing to provide written informed consent

You may not qualify if:

• Presence of disorders of the ocular media which interfere with visual acuity and other ocular assessments during the study period
• Eyes with other ocular pathology such as trauma, inflammation, previous intraocular surgery (except for cataract surgery)
• Systemic diseases that might affect ocular blood flow such as uncontrolled hypertension, autoimmune disease, and haematological disorders
• Pregnant or nursing women
• Persons who are unable to give informed consent

Sponsors & Collaborators

• Singapore National Eye Centre: lead
• National University Hospital, Singapore: collaborator
• University of Malaya: collaborator
• Hong Kong University: collaborator

Study Sites (4)

Hong Kong University

Hong Kong, Hong Kong

NOT YET RECRUITING

University of Malaya Medical Centre

Kuala Lumpur, Malaysia

RECRUITING

National University Hospital, Singapore

Singapore, Singapore

NOT YET RECRUITING

Singapore National Eye Centre/ Singapore Eye Research Institute

Singapore, Singapore

RECRUITING

Central Study Contacts

Gemmy Cheung

CONTACT

+65 63227460; gemmy.cheung.c.m@singhealth.com.sg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: November 14, 2025
• First Posted: November 19, 2025
• Study Start: March 4, 2025
• Primary Completion (Estimated): June 1, 2029
• Study Completion (Estimated): August 1, 2029
• Last Updated: November 28, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

HK (1); SG (2); MY (1)