The Ratio of Diaphragmatic Movement Between the Midaxillary Line and the Midclavicular Line Predicts the Success Rate of Weaning From Mechanical Ventilation

NCT07235956 | Not Yet Recruiting

• 1 other identifier: 2025LWB429
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study will provide individualized objective indicators for patients undergoing invasive mechanical ventilation. It will set specific assessment parameters for weaning and extubation for different patients, increase the success rate of weaning, avoid the damage and medical risks of re-intubation, and shorten the hospital stay. The main observation targets of this study are: whether weaning is successful; the secondary targets are: specific numerical values of diaphragmatic mobility along the midclavicular line and midaxillary line, oxygenation index, and whether re-intubation occurs within 48 hours. This study is an observational study. The expected study duration is 18 months, and there is no risk of study interruption.

Conditions

Mechanical Ventilation

Keywords

Diaphragmatic mobility; Invasive mechanical ventilation

Outcome Measures

Primary Outcomes (1)

• The success rate of weaning from invasive mechanical ventilation

  From enrollment to the outcome of extubation with invasive mechanical ventilation

Study Arms (1)

Group with successful extubation of invasive mechanical ventilation

Diagnostic Test: Observe the ratio of diaphragmatic excursion between the midaxillary line and the midclavicular line in the successful group of invasive mechanical ventilation weaning.

Interventions

Observe the ratio of diaphragmatic excursion between the midaxillary line and the midclavicular line in the successful group of invasive mechanical ventilation weaning. DIAGNOSTIC_TEST

Observe the ratio of diaphragmatic excursion between the midaxillary line and the midclavicular line in the successful group of invasive mechanical ventilation weaning.

Group with successful extubation of invasive mechanical ventilation

Eligibility Criteria

• Age: 14 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study is an observational cohort study. Patients who received invasive mechanical ventilation in the intensive care unit of our hospital from October 1, 2025 to December 31, 2026 were collected. The diaphragmatic excursion at the midclavicular line and the midaxillary line of each patient was measured using ultrasound, and the ratio of the diaphragmatic excursion at the two lines was calculated. The main content was to monitor the diaphragmatic excursion at the midclavicular line and the midaxillary line, and calculate the ratio; the monitoring time points were the first day, the third day, the seventh day (if applicable), the 14th day (if applicable), and before weaning and extubation, and at the same time, the patients' serum albumin, serum prealbumin, hemoglobin, oxygenation index, etc. were observed for treatment.

You may qualify if:

• Patients who were admitted to the ICU and had invasive mechanical ventilation for more than 72 hours.

You may not qualify if:

• Patients with irreversible multi-organ failure; Patients with advanced tumors

Sponsors & Collaborators

• Zheng Qingjiang: lead

Central Study Contacts

Qingjiang Zheng, Master of Clinical Medicine

CONTACT

8613799824987; qingjiang233@126.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 12 Months
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Attending

Study Record Dates

• First Submitted: September 23, 2025
• First Posted: November 19, 2025
• Study Start: December 1, 2025
• Primary Completion (Estimated): October 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: November 19, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share