Anesthetic Effectiveness of Lidocaine Versus Articaine in Dentistry

NCT07231614 | Not Yet Recruiting Phase 4 DMC

• 1 other identifier: ArtiVsLido
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Context: Lidocaine and articaine are two of the most commonly used local anesthetics in dentistry. Lidocaine has often been the anesthetic of choice in clinical practice, but in clinical experience, articaine has proven to be more effective in controlling pain during dental procedures. (Camps-Font, O. et al. 2020). There are still unanswered questions, such as which of the two local anesthetics is more effective in reducing pain? This could lead us to discuss which one to choose to reduce costs in the dental office. Objective: The objective of this project is to determine and compare the effectiveness of lidocaine and articaine in clinical contexts such as tooth extraction with infiltrative techniques, seeking to provide answers that will optimize the choice of anesthetic based on the patient and the procedure, thus improving pain management and reducing costs in the dental office. Design: Randomized double-blind experimental study, parallel groups. The control group received 2% lidocaine, and the experimental group received 4% articaine. The study will be conducted in accordance with the guidelines of the Consolidated Standards of Reporting Trials (CONSORT 2010). The probabilistic sampling technique is through simple randomization. The 100 patients who meet the inclusion criteria will be randomly assigned to the control and experimental groups in a 1:1 ratio. Expected results: articaine shows a lower percentage of extractions with anesthetic reinforcement and, therefore, a lower average number of additional tubes.

Conditions

Dental Pain

Keywords

nerve block; comparative study; exodontics; pain measurement; anesthesia infiltration

Outcome Measures

Primary Outcomes (1)

• Number of tubes

  continuous quantitative variable

  immediately after the procedure

Secondary Outcomes (1)

• Pain during dislocation using the Visual Analog Scale (VAS) for pain with a minimum of 0 meaning no pain, and a maximum of 10 meaning the most severe pain ever experienced in life.

  After the procedure

Other Outcomes (2)

• Age

  immediately after the procedure

• Sex

  Immediately after the procedure.

Study Arms (2)

Lidocaine

ACTIVE COMPARATOR

Participant in this group will receive lidocaine as a local anesthetic during dental procedures.

Drug: lidocaine + epinephrine 1:100,000

Articaine

EXPERIMENTAL

Participant in this group will receive articaine as a local anesthetic during dental procedures.

Drug: Articaine 4% with epinephrine 1:100,000

Interventions

lidocaine + epinephrine 1:100,000 DRUG

Administration of lidocaine as a local anesthetic during dental extraction.

Lidocaine

Articaine 4% with epinephrine 1:100,000 DRUG

Administration of articaine as a local anesthetic during dental extraction.

Articaine

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with clinical indications for simple extraction of upper and lower teeth using infiltrative anesthetic techniques.
• Patients without systemic diseases (ASA I)
• Patients with controlled systemic disease (ASA II)
• Patients with no history of hypersensitivity to anesthetics or their components (epinephrine)
• Patients with stable periodontal condition, without active infection that could affect the diffusion of the anesthetic.
• Patients with the ability to understand the procedure and provide informed consent.

You may not qualify if:

• Patients with uncontrolled systemic diseases ASA III and pregnant patients.
• Patients requiring trunk techniques (Gow gates, Spix, Carrea)
• Patients taking medication that affects the anesthetic response (tricyclic antidepressants, anticoagulants)
• Patients with a history of neurological or psychiatric disorders that may influence the perception of pain or anxiety.
• Patients with anatomical abnormalities in the orofacial region that interfere with the administration or action of anesthesia.
• Patients with a history of recent substance abuse.

Sponsors & Collaborators

• Universidad Austral de Chile: lead

Study Sites (1)

CESFAM Dr. Jorge Sabat

Valdivia, Los Ríos Region, 5090000, Chile

Location

Related Publications (1)

• Halabi D, Escobar J, Alvarado C, Martinez N, Munoz C. Chlorhexidine for prevention of alveolar osteitis: a randomised clinical trial. J Appl Oral Sci. 2018;26:e20170245. doi: 10.1590/1678-7757-2017-0245. Epub 2018 May 7.

  PMID: 29742264 RESULT

Related Links

• Document that describes in detail the objectives, methodology, and procedures of the clinical trial.

MeSH Terms

Conditions

Toothache

Interventions

Lidocaine; Epinephrine; Carticaine

Condition Hierarchy (Ancestors)

Tooth Diseases; Stomatognathic Diseases; Facial Pain; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Acetanilides; Anilides; Amides; Organic Chemicals; Aniline Compounds; Amines; Ethanolamines; Amino Alcohols; Alcohols; Biogenic Monoamines; Biogenic Amines; Catecholamines; Catechols; Phenols; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons; Thiophenes; Sulfur Compounds; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds

Study Officials

• Juan E Kunstmann, Dr. Dental Surgeon Dentistry

  Universidad Austral de Chile

  STUDY DIRECTOR

Central Study Contacts

Natalia A Curín, Student

CONTACT

+56947029930; natalia.curin@alumnos.uach.cl

Camila A Henriquez, Student

CONTACT

+56954911248; camilantonia.12345@gmail.com

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, CARE PROVIDER
• Masking Details: Blinding will be performed by the study investigators. The RCT is a double-blind trial, where neither the operator nor the patient knows the result of the anesthesia being administered. The preparation of the intervention will be carried out by dividing the anesthetic cartridges, 50 for the control group (lidocaine) and 50 for the experimental group (articaine). Since both articaine and lidocaine are from the same manufacturer, they have the same color silicone plunger, so we will simply cover the logo with an adhesive sticker and store them in a box. To distinguish which of the tubes corresponds to articaine or lidocaine once they have the sticker, they will be assigned the same numbers that will be used to randomize each patient (1 and 2 interleaved), with No. 1 being articaine and No. 2 being lidocaine. These will be in their respective boxes with their numbering.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Randomized, double-blind, parallel-group experimental study. Control group: 2% lidocaine; experimental group: 4% articaine. The RCT will be conducted in accordance with the Consolidated Standards of Reporting Trials (CONSORT 2010) guidelines.

Study Record Dates

• First Submitted: August 27, 2025
• First Posted: November 17, 2025
• Study Start: December 20, 2025
• Primary Completion: December 25, 2025
• Study Completion: January 25, 2026
• Last Updated: November 17, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will share

Locations

CL (1)