NCT07228871

Brief Summary

The aim of this study is to evaluate the effectiveness of continuous Theta Burst Stimulation added to mirror therapy on neglect associated with stroke.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
22

participants targeted

Target at below P25 for not_applicable

Timeline
9mo left

Started Jan 2026

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress32%
Jan 2026Jan 2027

First Submitted

Initial submission to the registry

November 13, 2025

Completed
1 day until next milestone

First Posted

Study publicly available on registry

November 14, 2025

Completed
2 months until next milestone

Study Start

First participant enrolled

January 1, 2026

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 31, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 31, 2027

Last Updated

February 24, 2026

Status Verified

November 1, 2025

Enrollment Period

1.1 years

First QC Date

November 13, 2025

Last Update Submit

February 22, 2026

Conditions

Hemispatial Neglect

Keywords

neglectmirror therapytheta burst stimulation

Outcome Measures

Primary Outcomes (1)

  • Catherine Bergego Scale

    Before Treatment and 2nd week of treatment

Secondary Outcomes (3)

  • Verbal and Nonverbal Cancellation Test

    Before Treatment and 2nd week of treatment

  • Line Bisection Test

    Before Treatment and 2nd week of treatment

  • Barthel Index

    Before Treatment and 2nd week of treatment

Study Arms (2)

Active cTBS + mirror therapy group

EXPERIMENTAL
Other: Mirror TherapyDevice: cTBSOther: Cognitive rehabilitation

Sham cTBS + mirror therapy

SHAM COMPARATOR
Other: Mirror TherapyOther: Cognitive rehabilitation

Interventions

cTBSDEVICE

Patients received cTBS applied to the P3 region according to the 10/20 electroencephalogram system for 5 days a week, totalling 10 sessions over 2 weeks.

Active cTBS + mirror therapy group
Mirror TherapyOTHER

Mirror therapy will be administered 5 days a week for 2 weeks.

Active cTBS + mirror therapy groupSham cTBS + mirror therapy
Cognitive rehabilitationOTHER

Methods that facilitate adaptation in daily life activities will be taught.

Active cTBS + mirror therapy groupSham cTBS + mirror therapy

Eligibility Criteria

Age18 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Ischemic/haemorrhagic stroke
  • Right hemisphere lesion
  • Patients with a duration of more than 7 days but less than 1 year from the date of the event
  • Aged between 18 and 75 years
  • Patients with a Mini Mental Test Score ≥ 24

You may not qualify if:

  • History of recurrent stroke
  • Presence of vision or hearing problems
  • Use of medication affecting cognitive function
  • History of epilepsy
  • Pregnancy or breastfeeding
  • History of malignancy
  • Pacemaker
  • Presence of metallic implants in the brain or scalp (including cochlear implant)
  • History of premorbid dementia
  • Presence of psychiatric or additional neurological disease

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Ankara Etlik City Hospital

Ankara, Yenimahalle, 06010, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Perceptual Disorders

Interventions

Mirror Movement TherapyCognitive Training

Condition Hierarchy (Ancestors)

Neurobehavioral ManifestationsNeurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Physical Therapy ModalitiesRehabilitationTherapeuticsNeurological RehabilitationAftercareContinuity of Patient CarePatient CareHealth ServicesHealth Care Facilities Workforce and Services

Central Study Contacts

Ayşe Naz Kalem Özgen, specialist

CONTACT

+90 0312 797 00 00kalemnaz@gmail.com

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER GOV
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
PM&R Specialist

Study Record Dates

First Submitted

November 13, 2025

First Posted

November 14, 2025

Study Start

January 1, 2026

Primary Completion (Estimated)

January 31, 2027

Study Completion (Estimated)

January 31, 2027

Last Updated

February 24, 2026

Record last verified: 2025-11

Locations

TU(1)