Impact of Resistance Training With and Without Venous Occlusion on Strength and Function Post (Hand Burn)

NCT07228780 | Completed DMC

• 1 other identifier: P.T.REC/012/006079
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

It will be hypothesized that There is There is no difference between resistance training with and without venous occlusion on hand strength and function post hand burn.

Conditions

Hand Burn

Keywords

hand burn-hand grip

Outcome Measures

Primary Outcomes (1)

• hand grip strength

  Hand grip will be assessed by digital Hand Dynamometer

  twice first before beginning treatment from day 1 of treatment second after complete treatment after 1 month Assessment will be for 1 minute For assessment hand grip strength

Secondary Outcomes (1)

• upper limb function

  twice first pre treatment at 1 day for almost 5 minutes to assess all functions of upper limb function second after complete treatment after 1 month to assess upper limb function after treatment for 5 minutes

Study Arms (2)

study group (aspirin Group)

EXPERIMENTAL

Resistance exercises with venous occlusion This group will include 17 patients with hand burn who will receive treatment for burn which included: positioning, range of motion, stretch, joint mobilization and strength exercise for hand grip with blood flow restriction3 days per week for 4 weeks

Other: resistance exercise with venous occlusion

control

EXPERIMENTAL

This group will include 17 patients with hand burn who will receive treatment for burn which included: positioning, range of motion, stretch, joint mobilization and strength exercise for hand grip with blood flow restriction3 days per week for 4 weeks

Other: traditional resistance exercises

Interventions

resistance exercise with venous occlusion OTHER

patients with hand burn who will receive conventional treatment for burn which included: positioning, range of motion, stretch, joint mobilization and strength exercise for hand grip for 3 days per week for 4 weeks

study group (aspirin Group)

traditional resistance exercises OTHER

This group will include 17 patients with hand burn who will receive conventional treatment for burn which included: positioning, range of motion, stretch, joint mobilization and strength exercise for hand grip for 3 days per week for 4 weeks

control

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients of all age groups and both sexes having less than sixty percent TBSA thermal burns and involves the hand.
• Patients with second-degree (superficial or deep) burn on the hand.
• Patients with third-degree burns
• Patients with complete wound healing
• Patients without any defects at tendons
• Patients without burning at cubital fossa (cuff placement)
• participants were required to have a resting (systolic and diastolic) blood pressure of \<140/90 mmHg and a resting heart rate of \<90 bpm
• A decreased grip strength.
• Patients without cognitive impairments and actively cooperating with treatment and measurements

You may not qualify if:

• Any patient who has previous injury or congenital deformity of the hand with restricted hand function.
• Resting systolic BP (BP) \<140 mmHg and/or diastolic BP\< 90 mmHg
• Self-reported cardiovascular, metabolic, or pulmonary conditions or signs and symptoms suggestive of these diseases
• Associated injuries affecting participation in exercise training, including fracture, amputation, acquired brain injury or peripheral neural injury or any pre-existing medical condition which may affect exercise participation.
• patients that had fourth degree burns
• patients that had first degree burns
• Patients with burn at cubital fossa (cuff placement)
• Patients without complete wound healing
• patient who is taking medications that affect hemodynamic responses
• Patients with severe hand burns leading to muscle and tendon damage, or those who have undergone finger amputation surgery
• Patients who were not compliant for following up for at least once a month following discharge from hospital.

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Unknown Facility

Gharbia, Elmahalla Elkubra, 3365, Egypt

Location

Related Publications (33)

• Araujo, B. F., do Nascimento, C. M., Busarello, F. O., Moreira, N. B., Baroni, M. P., de Carvalho, A. R., & Bertolini, G. R. F. (2012). Assessment of handgrip strength after neural mobilization. Revista Brasileira de Medicina do Esporte, 18(4), 242-245.

  RESULT

• Ahmed, A. M., Hassan, Y. S., Azer, S. Z., & Abd EL-All, H. A. E. R. (2019). Effect of range of motion exercise program on improving upper-arm region joints function for burned patients. Assiut Scientific Nursing Journal, 7(19), 61-69.

  RESULT

• Watzinger N, Hecker A, Petschnig D, Tran J, Glantschnig C, Moshammer M, Pignet AL, Ellersdorfer AM, Kamolz LP. Long-Term Functional Outcomes after Hand Burns: A Monocentric Controlled Cohort Study. J Clin Med. 2024 Jun 15;13(12):3509. doi: 10.3390/jcm13123509.

  PMID: 38930038 RESULT

• Watson R, Sullivan B, Stone A, Jacobs C, Malone T, Heebner N, Noehren B. Blood Flow Restriction Therapy: An Evidence-Based Approach to Postoperative Rehabilitation. JBJS Rev. 2022 Oct 3;10(10). doi: 10.2106/JBJS.RVW.22.00062. eCollection 2022 Oct 1.

  PMID: 36191086 RESULT

• Tehreem, Z., Kazmi, Y., Khalid, M. U., Mansha, H., Hassan, M., & Majeed, R. (2022). Comparison of soft tissue mobilization versus static stretching in post-burn contractures at elbow and wrist, A pilot study. Journal of University Medical & Dental College, 13(3), 408-411.

  RESULT

• Serghiou M, Cowan A, Whitehead C. Rehabilitation after a burn injury. Clin Plast Surg. 2009 Oct;36(4):675-86. doi: 10.1016/j.cps.2009.05.008.

  PMID: 19793561 RESULT

• Schoenfeld BJ. The mechanisms of muscle hypertrophy and their application to resistance training. J Strength Cond Res. 2010 Oct;24(10):2857-72. doi: 10.1519/JSC.0b013e3181e840f3.

  PMID: 20847704 RESULT

• Salwa, F., KHATTAB, A. S., MOHAMMED, M. M., & NASER, M. A. (2020). Validity and reliability of the Arabic version of the quick-dash questionnaire for upper extremity disorders. The Medical Journal of Cairo University, 88(December), 2037-2043

  RESULT

• Reina-Ruiz AJ, Martinez-Cal J, Molina-Torres G, Romero-Galisteo RP, Galan-Mercant A, Carrasco-Vega E, Gonzalez-Sanchez M. Effectiveness of Blood Flow Restriction on Functionality, Quality of Life and Pain in Patients with Neuromusculoskeletal Pathologies: A Systematic Review. Int J Environ Res Public Health. 2023 Jan 12;20(2):1401. doi: 10.3390/ijerph20021401.

  PMID: 36674158 RESULT

• Prolonge, R. (2022). Hand and Wrist Mobilizations. In: Mesplié, G. (eds) Hand and Wrist Therapy. Springer, Cham. https://doi.org/10.1007/978-3-030-94942-6_5

  RESULT

• Procter F. Rehabilitation of the burn patient. Indian J Plast Surg. 2010 Sep;43(Suppl):S101-13. doi: 10.4103/0970-0358.70730.

  PMID: 21321643 RESULT

• Perera, A. D., Perera, C., & Karunanayake, A. L. (2017). Effectiveness of early stretching exercises for range of motion in the shoulder joint and quality of functional recovery in patients with burns-a randomized control trial.

  RESULT

• Mohammadabadi, H. D., Azizi, S., Dadarkhah, A., & Soltani, Z. R. (2018). Evaluation of effectiveness of the wrist mobilization compared with local corticosteroid injection in treatment of moderate carpal tunnel syndrome. Annals of Military and Health Sciences Research, 16(2), e83335.

  RESULT

• Machek, S. B., Harris, D. R., Heileson, J. L., Wilburn, D. T., Forsse, J. S., & Willoughby, D. S. (2023). Impacts of varying blood flow restriction cuff size and material on arterial, venous and calf muscle pump-mediated blood flow. Oxygen, 3(2), 190-202

  RESULT

• Kara S, Seyhan N, Oksuz S. Effectiveness of early rehabilitation in hand burns. Ulus Travma Acil Cerrahi Derg. 2023 Jun;29(6):691-697. doi: 10.14744/tjtes.2023.22780.

  PMID: 37278077 RESULT

• Joseph, S. (2022). The effective management and outcome of hand burns. *Journal of Clinical Research and Reports, 10*(1). https://doi.org/10.31579/2690-1919/213

  RESULT

• Hornikel B, Saffold KS, Esco MR, Mota JA, Fedewa MV, Wind SA, Adams TL, Winchester LJ. Acute Responses to High-Intensity Back Squats with Bilateral Blood Flow Restriction. Int J Environ Res Public Health. 2023 Feb 17;20(4):3555. doi: 10.3390/ijerph20043555.

  PMID: 36834246 RESULT

• Heiser R, O'Brien VH, Schwartz DA. The use of joint mobilization to improve clinical outcomes in hand therapy: a systematic review of the literature. J Hand Ther. 2013 Oct-Dec;26(4):297-311; quiz 311. doi: 10.1016/j.jht.2013.07.004. Epub 2013 Sep 14.

  PMID: 24044954 RESULT

• Gün, N., Kavlak, B., Sarı, Z., & Yurdalan, S. U. (2023). The effect of neural mobilization on muscle strength, reaction time, and pain threshold. *Turkish Journal of Science and Health, 4*(2), 155-162. https://doi.org/10.51972/tfsd.1233200

  RESULT

• Gittings P, Salet M, Burrows S, Ruettermann M, Wood FM, Edgar D. Grip and Muscle Strength Dynamometry Are Reliable and Valid in Patients With Unhealed Minor Burn Wounds. J Burn Care Res. 2016 Nov/Dec;37(6):388-396. doi: 10.1097/BCR.0000000000000414.

  PMID: 27606549 RESULT

• Franz A, Ji S, Froschen FS, Kerstin M, Wahl P, Behringer M. Effects of low-load blood flow restriction on the venous system in comparison to traditional low-load and high-load exercises. Front Physiol. 2023 Dec 15;14:1285462. doi: 10.3389/fphys.2023.1285462. eCollection 2023.

  PMID: 38162828 RESULT

• Franz A, Ji S, Bittersohl B, Zilkens C, Behringer M. Impact of a Six-Week Prehabilitation With Blood-Flow Restriction Training on Pre- and Postoperative Skeletal Muscle Mass and Strength in Patients Receiving Primary Total Knee Arthroplasty. Front Physiol. 2022 Jun 14;13:881484. doi: 10.3389/fphys.2022.881484. eCollection 2022.

  PMID: 35774280 RESULT

• 15. Filippou, S., Iakovidis, P., Lytras, D., Kasimis, K., Solomonidou, F., & Kopsidas, C. (2023). Hemodynamic Responses to a Handgrip Exercise Session, with and without Blood Flow Restriction, in Healthy Volunteers. Physiologia, 3(2), 259-271.

  RESULT

• Fernandes DZ, Weber VMR, da Silva MPA, de Lima Stavinski NG, de Oliveira LEC, Casoto Tracz EH, Ferreira SA, da Silva DF, Queiroga MR. EFFECTS OF BLOOD FLOW RESTRICTION TRAINING ON HANDGRIP STRENGTH AND MUSCULAR VOLUME OF YOUNG WOMEN. Int J Sports Phys Ther. 2020 Dec;15(6):901-909. doi: 10.26603/ijspt20200901.

  PMID: 33344006 RESULT

• Edger-Lacoursiere Z, Deziel E, Nedelec B. Rehabilitation interventions after hand burn injury in adults: A systematic review. Burns. 2023 May;49(3):516-553. doi: 10.1016/j.burns.2022.05.005. Epub 2022 May 14.

  PMID: 35662480 RESULT

• Credeur DP, Hollis BC, Welsch MA. Effects of handgrip training with venous restriction on brachial artery vasodilation. Med Sci Sports Exerc. 2010 Jul;42(7):1296-302. doi: 10.1249/MSS.0b013e3181ca7b06.

  PMID: 20019641 RESULT

• 10. Costa, C. R. M., Dos-Santos, R. C., Paula, W. V., Ribeiro, W. M. V., & Silveira, A. L. B. (2017). Acute static muscle stretching improves manual dexterity in young men. *MedicalExpress (São Paulo, online), 4*(3), M170306. https://doi.org/10.5935/MedicalExpress.2017.03.06

  RESULT

• 8. Cerqueira, M. S., Pereira, R., Mesquita, G. N. D., Rocha, T., & Moura Filho, A. G. D. (2019). Rate of force development to evaluate the neuromuscular fatigue and recovery after an intermittent isometric handgrip task with different blood flow restriction conditions. Motriz: Revista de Educação Física, 25(1), e1019123.

  RESULT

• Bryant J, Cooper DJ, Peters DM, Cook MD. The Effects of Static Stretching Intensity on Range of Motion and Strength: A Systematic Review. J Funct Morphol Kinesiol. 2023 Mar 24;8(2):37. doi: 10.3390/jfmk8020037.

  PMID: 37092369 RESULT

• Bond CW, Hackney KJ, Brown SL, Noonan BC. Blood Flow Restriction Resistance Exercise as a Rehabilitation Modality Following Orthopaedic Surgery: A Review of Venous Thromboembolism Risk. J Orthop Sports Phys Ther. 2019 Jan;49(1):17-27. doi: 10.2519/jospt.2019.8375. Epub 2018 Sep 12.

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  PMID: 15866967 RESULT

• Araujo CG, Duarte CV, Goncalves Fde A, Medeiros HB, Lemos FA, Gouvea AL. Hemodynamic responses to an isometric handgrip training protocol. Arq Bras Cardiol. 2011 Nov;97(5):413-9. doi: 10.1590/s0066-782x2011005000102. Epub 2011 Oct 21. English, Portuguese.

  PMID: 22011802 RESULT

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: physical therapist

Study Record Dates

• First Submitted: November 13, 2025
• First Posted: November 14, 2025
• Study Start: November 20, 2025
• Primary Completion: January 1, 2026
• Study Completion: January 30, 2026
• Last Updated: April 14, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)