Mixed-Reality Visual Attention Task for Neglect Diagnosis and Rehabilitation

NCT07227844 | Not Yet Recruiting FDA Device

• 1 other identifier: 26-500-131-30-06
• Study Type: interventional
• Target: 5
• Locations: 1 country
• Sites: 1

Brief Summary

Neglect, a common and disabling neurological deficit post-CNS injury, profoundly hinders recovery and escalates healthcare costs. Current diagnostic tools are often insensitive or impractical, and while therapies exist, a significant research gap remains. Traditional methods, including standardized scales and paper-pencil tests, lack precision; even advanced video oculography is limited by cost and accessibility. Rehabilitative approaches like visual scanning and prism adaptation offer some benefit, but more effective solutions are needed. This project utilizes a non-invasive neuromodulatory training approach via a mixed-reality visual attention task delivered through a virtual reality headset. This system aims to improve both neglect diagnosis and personalized therapeutic intervention. The study will assess the headset's safety and practicality, its capacity to detect and lateralize neglect, and its long-term effect on improving attention to the neglected field. By measuring reaction times to visual stimuli within the VR environment, the research seeks to develop a more accessible and impactful tool for both assessing and treating neglect, potentially enabling self-directed therapy and enhancing patient outcomes.

Conditions

Neglect, Sensory; Neglect, Hemispatial; Neglect, Hemisensory

Keywords

neglect

Outcome Measures

Primary Outcomes (1)

• Improvement in Neglect

  Measured as improvement in percentage of lines detected at each location in the VR app

  6 months

Secondary Outcomes (2)

• Feasibility/Usage, sessions

  6 months

• Feasibility/Usage, time

  6 months

Study Arms (1)

Treatment

EXPERIMENTAL

Device: VR Neglect Training

Interventions

VR Neglect Training DEVICE

VR Neglect Training

Treatment

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• The study will involve patients over the age of 18 who have been diagnosed with a neurological injury that includes: ischemic stroke, hemorrhagic stroke, tumor, or trauma.
• Neurological injury that localizes to only one side of the brain
• At least one hand that retains dexterity enough to use a controller to extinguish the visual stimulus.
• Cognitive ability to understand simple instructions on how to use the device
• Visual fields intact

You may not qualify if:

• Bilateral symptomatic injury
• Inability to consent or to comply with study
• Blindness or severe visual deficits other than neglect

Sponsors & Collaborators

• Markey Olson: lead

Study Sites (1)

Barrow Neurological Institute

Phoenix, Arizona, 85013, United States

Location

MeSH Terms

Conditions

Perceptual Disorders

Condition Hierarchy (Ancestors)

Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Markey Olson, PhD

CONTACT

602-406-5944; neuromodulationresearch@commonspirit.org

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Research Manager

Study Record Dates

• First Submitted: November 7, 2025
• First Posted: November 13, 2025
• Study Start: December 31, 2025
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: November 13, 2025

Record last verified: 2025-11

Locations

US (1)