NCT07225777|TerminatedPhase 2DMCFDA Drug
Study Stopped
Funding status change.
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Funding status change.
Sponsor study identifier
Secondary identifiers
NIH
interventional
5
1 country
1
Study Start
April 27, 2026
Actual (reported)Primary Completion
August 31, 2026
Actual (reported)Study Completion
August 31, 2026
Actual (reported)This study investigates sex differences in reward processing following acute THC administration in adults with cannabis use disorder (CUD). Using multimodal neuroimaging (MRS and fMRI), the study will assess glutamate levels in the nucleus accumbens and striatal BOLD response to monetary reward anticipation. Participants will complete two counterbalanced dosing sessions (oral THC 40 mg vs. placebo).
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 31, 2026
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 5, 2025
Actual (reported)November 10, 2025
Actual (reported)April 27, 2026
Actual (reported)August 31, 2026
Actual (reported)August 31, 2026
Actual (reported)Nucleus accumbens glutamate
Concentrations of nucleus accumbens glutamate measured via proton magnetic resonance spectroscopy
2 hours post-dose
Striatal reward anticipation
Blood oxygen-level-dependent (BOLD) signaling in the striatum (caudate, putamen, nucleus accumbens) measured using functional magnetic resonance imaging (fMRI) during a monetary reward task
3 hours post-dose
Drug Effects Questionnaire (DEQ) - Like Drug Effect
0-7 hours
Drug Effects Questionnaire (DEQ) - Want More
0-7 hours
Drug Effects Questionnaire (DEQ) - High
0-7 hours
Nucleus accumbens GABA
2 hours post-dose
Oral dronabinol capsules (40 mg)
Matched placebo capsules
Medical University of South Carolina
Charleston, South Carolina, 29403, United States
Erin Martin, Ph.D.
Medical University of South Carolina
5 participants (actual enrollment reported by the registry).
First Submitted
November 5, 2025
First Posted
November 10, 2025
Study Start
April 27, 2026
Actual (reported)A Study of Cannabidiol in Young Adult Cannabis Users
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
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Primary Completion
August 31, 2026
Actual (reported)Study Completion
August 31, 2026
Actual (reported)Last Updated
October 6, 2026
Record last verified: 2026-10
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Source: ClinicalTrials.gov.
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