Feasibility of High Intensity Interval Training in Survivors of Childhood, Adolescent, and Young Adult Hodgkin Lymphoma

NCT07222345 | Recruiting

• 1 other identifier: FITHOD
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

This pilot study evaluates the feasibility of a 12-week high intensity interval training (HIIT) program in survivors of childhood, adolescent, and young adult Hodgkin lymphoma within 24 months of completing treatment. Preliminary efficacy of the HIIT intervention for improved cardiorespiratory fitness, body composition, physical function, autonomic response to exercise, peripheral neuropathy, biological aging markers, and physical activity will also be evaluated. Primary Objective: To determine the feasibility of a 12-week high intensity interval training (HIIT) program in survivors of childhood, adolescent, and young adult Hodgkin lymphoma within 24 months of completing treatment. Feasibility will be assessed by:

• Participation Rate: Number of eligible survivors approached who enroll.
• Completion Rate: Number of scheduled HIIT sessions attended and number of enrolled participants who complete post-intervention testing.

Conditions

Hodgkin Lymphoma

Keywords

Childhood Cancer Survivor

Outcome Measures

Primary Outcomes (2)

• Participation rate (percent of eligible participants approached who enroll)

  Descriptive statistics will be reported

  Trial completion (12 weeks)

• Completion rate (percentage of scheduled HIIT sessions attended and percentage of post-intervention testing sessions completed)

  Descriptive statistics will be reported

  Trial completion (12 weeks)

Other Outcomes (15)

• Cardiorespiratory fitness (VO2peak, ml/kg/min)

  baseline at study entry, 12 weeks

• Ewing battery score of autonomic function (0 to 5 points)

  baseline at study entry, 12 weeks

• Body mass index (weight and height will be combined to report body mass index in kg/m2)

  baseline at study entry, 12 weeks

Study Arms (1)

HIIT Intervention Group

EXPERIMENTAL

Participants will complete a 12-week HIIT program with three 25-minute sessions per week. Each session includes warm-up, five cycles of high-intensity intervals (80-95% peak HR) and recovery periods (50-60% peak HR), and cool-down.

Behavioral: High Intensity Interval Training (HIIT)

Interventions

High Intensity Interval Training (HIIT) BEHAVIORAL

Participants will complete a 12-week HIIT program with three 25-minute sessions per week. Each session includes warm-up, five cycles of high-intensity intervals (80-95% peak HR) and recovery periods (50-60% peak HR), and cool-down.

HIIT Intervention Group

Eligibility Criteria

• Age: 10 Years - 25 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Participant has been diagnosed with Hodgkin lymphoma between the ages of 10 to 25 years.
• Participant is between the ages of \>10 and \<25 years old the time of enrollment.
• Participant has completed treatment (end of chemotherapy for those not receiving radiation therapy or end of radiation therapy) for Hodgkin lymphoma within 24 months prior to enrollment and recovered from any acute treatment-related adverse events.
• Participant has been medically cleared to participate in physical activity.
• Participant verbalizes understanding of directions for use of the web-based platform on the study provided iPad and heart rate monitor.

You may not qualify if:

• Participant has evidence of relapsed disease.
• Participant has a diagnosis of acute heart failure.
• Participant reports currently participating in HIIT training or \>420 minutes per week of moderate to vigorous physical activity.
• Female participant who is currently pregnant.

Sponsors & Collaborators

• St. Jude Children's Research Hospital: lead

Study Sites (1)

St. Jude Children's Research Hospital

Memphis, Tennessee, 38105, United States

RECRUITING

Related Links

• St. Jude Children's Research Hospital
• Clinical Trials Open at St. Jude

MeSH Terms

Conditions

Hodgkin Disease

Interventions

High-Intensity Interval Training

Condition Hierarchy (Ancestors)

Lymphoma; Neoplasms by Histologic Type; Neoplasms; Lymphoproliferative Disorders; Lymphatic Diseases; Hemic and Lymphatic Diseases; Immunoproliferative Disorders; Immune System Diseases

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Amy Berkman, MD

  St. Jude Children's Research Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Amy Berkman, MD

CONTACT

888-226-4343; referralinfo@stjude.org

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 27, 2025
• First Posted: October 29, 2025
• Study Start: April 1, 2026
• Primary Completion (Estimated): January 1, 2028
• Study Completion (Estimated): January 1, 2029
• Last Updated: April 23, 2026

Record last verified: 2026-04

Locations

US (1)