NCT07221305

Brief Summary

The purpose of this study is to assess both the feasibility and efficacy of a 6-week mobile-application-based neuromuscular training program in high school athletes by measuring adherence rates and examining changes in agility and neuromuscular control. Outcomes were measured both during the intervention (adherence) as well as at pre- and post-intervention data collection sessions.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
19

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jul 2023

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 2, 2023

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 22, 2023

Completed
7 days until next milestone

Study Completion

Last participant's last visit for all outcomes

October 29, 2023

Completed
2 years until next milestone

First Submitted

Initial submission to the registry

October 23, 2025

Completed
4 days until next milestone

First Posted

Study publicly available on registry

October 27, 2025

Completed
Last Updated

October 30, 2025

Status Verified

October 1, 2025

Enrollment Period

4 months

First QC Date

October 23, 2025

Last Update Submit

October 28, 2025

Conditions

Neuromuscular ControlHealthyAthletic Performance and Injury Risk

Keywords

Neuromuscular Control TrainingInjury PreventionHigh School Athletes

Outcome Measures

Primary Outcomes (1)

  • Compliance

    Compliance with the RIIP REPS mobile program was defined by how many sessions were completed by each participant. Full compliance consisted of the recommended four sessions per week for a total of 24 sessions over the 6 week period. Adherence tiers were determined based on the number of sessions completed and were as follows: low adherence (\<12 sessions), and high adherence (\>12 sessions).

    Throughout the 6 week intervention

Secondary Outcomes (2)

  • Movement Quality

    Testing was performed before and within 2 weeks after the 6 week intervention.

  • Agility T Test

    Testing was performed before and within 2 weeks after the 6 week intervention.

Study Arms (1)

Neuromuscular Control Training Program

EXPERIMENTAL

The intervention was a self-paced neuromuscular control training program that athletes completed on their mobile phones via the RIIP REPS app. Athletes were instructed to complete 4 sessions per week throughout the 6 week intervention.

Other: Neuromuscular Control Training

Interventions

Neuromuscular Control TrainingOTHER

The mobile app-based neuromuscular control training program was administered via the RIIP REPS application. The program consisted of 24 unique 7-minute sessions. Each session emphasized bodyweight training targeting landing mechanics, trunk and hip control, balance, and posterior chain engagement. The sessions progressed in difficulty throughout the intervention.

Also known as: Neuromuscular Training, NMT
Neuromuscular Control Training Program

Eligibility Criteria

Age14 Years - 18 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • Age 14-18
  • Actively participating in an organized sport OR have participated in an organized sport in the last 12 months
  • Pre-intervention testing completed AND post-intervention testing completed within 2 weeks of completing the 6 week program

You may not qualify if:

  • Individuals whose physical activity and/or sports participation is currently limited by an illness or injury
  • Individuals with previous lower extremity injury and/or surgery
  • Individuals who are not fluent in English
  • Individuals without access to an iOS or Android mobile phone

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Hospital for Special Surgery

New York, New York, 10021, United States

Location

Related Publications (3)

  • Petushek EJ, Sugimoto D, Stoolmiller M, Smith G, Myer GD. Evidence-Based Best-Practice Guidelines for Preventing Anterior Cruciate Ligament Injuries in Young Female Athletes: A Systematic Review and Meta-analysis. Am J Sports Med. 2019 Jun;47(7):1744-1753. doi: 10.1177/0363546518782460. Epub 2018 Jul 12.

    PMID: 30001501BACKGROUND

  • Steib S, Rahlf AL, Pfeifer K, Zech A. Dose-Response Relationship of Neuromuscular Training for Injury Prevention in Youth Athletes: A Meta-Analysis. Front Physiol. 2017 Nov 14;8:920. doi: 10.3389/fphys.2017.00920. eCollection 2017.

    PMID: 29184511BACKGROUND

  • Di Paolo S, Musa F, d'Orsi GM, Grassi A, Vulpiani MC, Zaffagnini S, Della Villa F. A comprehensive two-dimensional scoring system to assess the single-leg squat task in football players. Knee. 2024 Jun;48:52-62. doi: 10.1016/j.knee.2024.02.016. Epub 2024 Mar 20.

    PMID: 38513322BACKGROUND

Study Officials

  • Andrew D Pearle, M.D.

    Hospital for Special Surgery, New York

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
PREVENTION
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 23, 2025

First Posted

October 27, 2025

Study Start

July 2, 2023

Primary Completion

October 22, 2023

Study Completion

October 29, 2023

Last Updated

October 30, 2025

Record last verified: 2025-10

Data Sharing

IPD Sharing
Will not share

Locations

US(1)