Remapping Text in Sentence and Word Tasks to Aid Reading With Central Vision Loss

NCT07216924 | Not Yet Recruiting

• 1 other identifier: Remapping in reading tasks
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Reading performance in patients with Central Vision Loss will be measured with and without missing text being remapped to different parts of the visual field in a variety of different reading tasks.

Conditions

Macular Degeneration; Central Visual Impairment

Keywords

Reading; Central Field Loss

Outcome Measures

Primary Outcomes (6)

• Sentence reading speed

  Time it took to read sentence in words per minute

  Measured on day 35, end of the Personalised Remapping Training in the 33 participants in the Perceptual Learning arm.

• Sentence reading accuracy

  Percentage of correctly read words in sentence

  Measured on day 35, end of the Personalised Remapping Training in the 33 participants in the Perceptual Learning arm.

• Word reading speed: RSVP

  Time taken to read each word

  Measured on day 21, end of the RSVP Remapping intervention in the 33 participants in the Rapid Serial Visual Presentation arm.

• Word recognition accuracy: RSVP

  Percentage of words correctly read

  Measured on day 21, end of the RSVP Remapping intervention in the 33 participants in the Rapid Serial Visual Presentation arm.

• Word reading speed: Reading in The Wild

  Time taken to read each word

  Measured on day 21, end of the Reading Text in The Wild with Remapping intervention in the 33 participants in the Reading in The Wild arm.

• Word recognition accuracy: Reading in the wild

  Percentage of words correctly read

  Measured on day 21, end of the Reading Text in The Wild with Remapping intervention in the 33 participants in the Reading in The Wild arm.

Study Arms (3)

Perceptual Learning

EXPERIMENTAL

Participants will practice reading with remapping over many sessions on different days.

Behavioral: Personalised Remapping Training

Rapid Serial Visual Presentation

EXPERIMENTAL

Participants will read words presented one at a time in rapid succession near fixation.

Behavioral: RSVP personalized remappi

Reading in The Wild

EXPERIMENTAL

Participants will view scenes in virtual reality showing natural settings and read a single word at a time within those scenes- e.g. a name on a street sign or shop in a city scene.

Behavioral: Reading text in the wild with remapping

Interventions

Personalised Remapping Training BEHAVIORAL

Participants will receive training across multiple days with text being shifted in real time as it is being read from locations covered by scotoma to locations determined by personalization procedure .

Perceptual Learning

RSVP personalized remappi BEHAVIORAL

Participants will read one word at a time presented in rapid succession at fixation with text being shifted from scotoma locations to locations determined by personalization procedure.

Rapid Serial Visual Presentation

Reading text in the wild with remapping BEHAVIORAL

Participants will read short texts presented in natural scenes in virtual reality with text being shifted from scotoma locations to locations determined by personalization procedure.

Reading in The Wild

Eligibility Criteria

• Age: 16 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Dense bilateral scotomas of at least 2 deg diameter in each eye covering the fovea
• Bivariate contour ellipse area (BCEA) of less than 10\^2 is obtained in a simple fixation task

You may not qualify if:

• Neovascular AMD
• Any history of visual disorders other than that causing the central vision loss.

Sponsors & Collaborators

• University of Minnesota: lead

Study Sites (1)

University of Minnesota

Edina, Minnesota, 55416, United States

Location

MeSH Terms

Conditions

Macular Degeneration; Blindness, Cortical

Condition Hierarchy (Ancestors)

Retinal Degeneration; Retinal Diseases; Eye Diseases; Blindness; Vision Disorders; Sensation Disorders; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Stephen A Engel, Ph.D.

CONTACT

6126255571; engel@umn.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 22, 2025
• First Posted: October 15, 2025
• Study Start (Estimated): June 1, 2026
• Primary Completion (Estimated): May 1, 2031
• Study Completion (Estimated): May 1, 2032
• Last Updated: October 15, 2025

Record last verified: 2025-10

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP
• Time Frame: Data will be made available at the end of funding, or upon result publication, whichever comes first. As noted above all relevant publications will contain the DOI that points to the relevant data. The data will be stored as long as the OSF repository remains viable; if for some reason alternative storage sites are required within the next 10 years, the PI will pick from others available and transfer the data there.
• Access Criteria: We will store data on the Open Science Foundation (OSF) repository, available to most people. Computer code will be mirrored there and also stored as github repositories. We will take and store separate "snapshots" corresponding to published protocols and analyses to insure accessibility of older code as projects continue to develop. OSF allows for the creation of a DOI for projects, and a project/DOI pair will be created and associated with each aim of the present proposal. The DOI will be referenced in publications and presentations associated with each project. The behavioral data will be stored in a general purpose format (e.g. csv files), but posted analysis and presentation code will make use of MATLAB. While MATLAB is commercial software, most universities have site licenses available. The analysis code may also run in Octave, an open-source alternative to MATLAB.

Locations

US (1)